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Nampt activator-2

Name: Nampt activator-2
Brand: TargetMol
SKU: T72617
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T72617Cas No. 2237268-90-3

Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in the study of atherosclerosis, obesity, type II diabetes, insulin resistance, and type I diabetes.

Nampt activator-2

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Purity: 98.88%

Catalog No. T72617Cas No. 2237268-90-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$84	In Stock	In Stock
5 mg	$198	In Stock	In Stock
10 mg	$328	In Stock	In Stock
25 mg	$663	In Stock	In Stock
50 mg	$990	In Stock	In Stock
100 mg	$1,680	-	In Stock
500 mg	$3,390	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.88%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Nampt activator-2 is a NAMPT activator (EC50: 0.023 μM). Nampt activator-2 has an affinity for CYP2C9, 2D6, and 2C19 with affinity values of 0.060 μM, 0.41 μM, and 0.59 μM, respectively.Nampt activator-2 can be used in the study of atherosclerosis, obesity, type II diabetes, insulin resistance, and type I diabetes.
Targets&IC50	NAMPT:0.023 μM(EC50)
In vitro	Nampt activator-2 (compound 34) (10 μM; 4 h) significantly increases NMN and NAD levels in A549 lung epithelial cells.[1]
In vivo	Nampt activator-2 (compound 34) (1 mg/kg IV; 10 mg/kg PO; once) demonstrates low plasma clearance, substantial exposure, and excellent oral bioavailability (%F = 80).[1]

Chemical Properties

Molecular Weight	390.84
Formula	C₁₇H₁₅ClN₄O₃S
Cas No.	2237268-90-3
Smiles	S(=O)(=O)(C1=CC=C(NC(NCC=2C=NNC2)=O)C=C1)C3=CC=C(Cl)C=C3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (255.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5586 mL	12.7930 mL	25.5859 mL	127.9296 mL
5 mM	0.5117 mL	2.5586 mL	5.1172 mL	25.5859 mL
10 mM	0.2559 mL	1.2793 mL	2.5586 mL	12.7930 mL
20 mM	0.1279 mL	0.6396 mL	1.2793 mL	6.3965 mL
50 mM	0.0512 mL	0.2559 mL	0.5117 mL	2.5586 mL
100 mM	0.0256 mL	0.1279 mL	0.2559 mL	1.2793 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc