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10074-A4

Name: 10074-A4
Brand: TargetMol
SKU: T9628
Price: 54 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T9628Cas No. 312631-87-1

10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a "ligand cloud" around a "protein cloud", exhibiting distinct characteristics compared to a non-binding ligand.

10074-A4

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Purity: 99.06%

Catalog No. T9628Cas No. 312631-87-1

10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a "ligand cloud" around a "protein cloud", exhibiting distinct characteristics compared to a non-binding ligand.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$54	In Stock	In Stock
2 mg	$77	In Stock	In Stock
5 mg	$123	In Stock	In Stock
10 mg	$197	In Stock	In Stock
25 mg	$353	In Stock	In Stock
50 mg	$505	In Stock	In Stock
100 mg	$696	In Stock	In Stock
200 mg	$938	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.06%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	10074-A4 is a c-Myc binding compound that associates with c-Myc[370–409] and acts as a "ligand cloud" around a "protein cloud", exhibiting distinct characteristics compared to a non-binding ligand.
Targets&IC50	c-Myc:15.1 ± 2.3 μM(EC50), c-Myc:36.3 ± 9.0 μM(Kd)
In vitro	10074-A4 showed binding affinity with c-Myc370–409 with Kd of 36.3?±?9.0?μM and EC50 of 15.1?±?2.3?μM[2].10074-A4 arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells[2].

Chemical Properties

Molecular Weight	409.29
Formula	C₁₈H₁₄Cl₂N₂O₃S
Cas No.	312631-87-1
Smiles	OC(CN1C(=O)CSC1=O)Cn1c2ccc(Cl)cc2c2cc(Cl)ccc12
Relative Density.	No data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (244.33 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.77 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.4433 mL	12.2163 mL	24.4326 mL	122.1628 mL
5 mM	0.4887 mL	2.4433 mL	4.8865 mL	24.4326 mL
10 mM	0.2443 mL	1.2216 mL	2.4433 mL	12.2163 mL
20 mM	0.1222 mL	0.6108 mL	1.2216 mL	6.1081 mL
50 mM	0.0489 mL	0.2443 mL	0.4887 mL	2.4433 mL
100 mM	0.0244 mL	0.1222 mL	0.2443 mL	1.2216 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc