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Mc-Val-Cit-PAB-Cl

🥰Excellent
Catalog No. T18321Cas No. 1639351-92-0

Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.

Mc-Val-Cit-PAB-Cl

Mc-Val-Cit-PAB-Cl

🥰Excellent
Purity: 99.79%
Catalog No. T18321Cas No. 1639351-92-0
Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.
Pack SizePriceAvailabilityQuantity
1 mg$97In Stock
5 mg$245In Stock
10 mg$395In Stock
25 mg$743In Stock
50 mg$987In Stock
100 mg$1,370In Stock
200 mg$1,850In Stock
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Purity:99.79%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
Mc-Val-Cit-PAB-Cl, a cleavable ADC linker, is utilized in the conjugation of MMAE and antibodies to produce compounds such as antibody-MC-vc-MMAE (e.g., anti-CD22-MC-VC-PABC-MMAE), which demonstrate cytotoxicity with IC50s of 3.3 and 0.95 nM against BJAB and WSU cell lines, respectively.
Chemical Properties
Molecular Weight591.1
FormulaC28H39ClN6O6
Cas No.1639351-92-0
Smiles[C@@H](NC([C@@H](NC(CCCCCN1C(=O)C=CC1=O)=O)[C@H](C)C)=O)(C(NC2=CC=C(CCl)C=C2)=O)CCCNC(N)=O
Relative Density.1.278 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords

Mc-Val-Cit-PAB-ClMcValCitPABClMc Val Cit PAB ClInhibitorinhibitCleavableAntibody-drug conjugates linkersADCLinkerADC LinkersADC Linker
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