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SDU-071 (Synonyms: SDU071)

Name: SDU-071
Brand: TargetMol
SKU: T201391
Price: 65 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T201391 Copy Product Info

Purity: 99.54%

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SDU-071 is an orally active BRD4-p53 inhibitor, inhibiting the proliferation of MDA-MB-231 cells, blocking the interaction between BRD4 and the tumor suppressor p53, downregulating the expression of BRD4-targeted genes, thereby inhibiting cell proliferation, migration, and invasion, and inducing cell cycle arrest and apoptosis. SDU-071 is used for research on triple-negative breast cancer.

SDU-071

Copy Product Info

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Catalog No. T201391

Synonyms SDU071

Cas No. 3036109-10-8

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Pack Size	Price	USA Stock	Global Stock
1 mg	$65	-	In Stock
5 mg	$157	-	In Stock
10 mg	$237	-	In Stock
25 mg	$397	-	In Stock
50 mg	$598	-	In Stock
100 mg	$848	-	In Stock
200 mg	$1,130	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.54%

Appearance:Solid

Color:Yellow

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SDU-071 is an orally active BRD4-p53 inhibitor, inhibiting the proliferation of MDA-MB-231 cells, blocking the interaction between BRD4 and the tumor suppressor p53, downregulating the expression of BRD4-targeted genes, thereby inhibiting cell proliferation, migration, and invasion, and inducing cell cycle arrest and apoptosis. SDU-071 is used for research on triple-negative breast cancer.
In vitro	SDU-071 is a novel BRD4-p53 inhibitor. SDU-071 (10 μM, 24 h) inhibits the interaction of BRD4 with p53 tumor suppressor. [1]
In vivo	In an orthotopic mouse xenograft breast tumor model, SDU-071 (250 mg/kg, gavage, Once a day for 21 days) showed good antitumor activity. [1]
Synonyms	SDU071

Chemical Properties

Molecular Weight	435.52
Formula	C₂₈H₂₅N₃O₂
Cas No.	3036109-10-8
Smiles	COC(C=C1)=CC=C1NCC(C=C2NC3=CC=C(OC)C=C3)=NC4=C2C=CC5=C4C=CC=C5

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (183.69 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (9.18 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2961 mL	11.4805 mL	22.9611 mL	114.8053 mL
5 mM	0.4592 mL	2.2961 mL	4.5922 mL	22.9611 mL
10 mM	0.2296 mL	1.1481 mL	2.2961 mL	11.4805 mL
20 mM	0.1148 mL	0.5740 mL	1.1481 mL	5.7403 mL
50 mM	0.0459 mL	0.2296 mL	0.4592 mL	2.2961 mL
100 mM	0.0230 mL	0.1148 mL	0.2296 mL	1.1481 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc