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Sotagliflozin
(Synonyms: LX-4211, LP-802034) Copy Product Info
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Synonyms: LX-4211, LP-802034
Catalog No. T3547 Copy Product Info
Purity: 99.86%
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Sotagliflozin (LX-4211, LP-802034) is an oral dual inhibitor of sodium-glucose cotransporter 1/2 (SGLT1/SGLT2) (SGLT2, IC₅₀ ≈ 1.8 nM; SGLT1, IC₅₀ ≈ 36 nM) used as an antidiabetic agent. Sotagliflozin is used in research on cardiovascular disease and diabetes.
Cas No. 1018899-04-1
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $38 | In Stock | In Stock | |
| 2 mg | $52 | In Stock | In Stock | |
| 5 mg | $89 | In Stock | In Stock | |
| 10 mg | $133 | In Stock | In Stock | |
| 25 mg | $261 | In Stock | In Stock | |
| 50 mg | $397 | In Stock | In Stock | |
| 100 mg | $590 | In Stock | In Stock | |
| 500 mg | $1,260 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $90 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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Purity:99.86%
Color:White
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Sotagliflozin (LX-4211, LP-802034) is an oral dual inhibitor of sodium-glucose cotransporter 1/2 (SGLT1/SGLT2) (SGLT2, IC₅₀ ≈ 1.8 nM; SGLT1, IC₅₀ ≈ 36 nM) used as an antidiabetic agent. Sotagliflozin is used in research on cardiovascular disease and diabetes. |
| Targets & IC50 | SGLT2:0.6 nM (mouse), SGLT2:1.8 nM (human), SGLT1:62 nM (mouse), SGLT1:36 nM (human) |
| In vitro | LX4211 inhibits [14C]AMG uptake with IC50 of 62.0 nM for mouse SGLT1 and 0.6 nM for mouse SGLT2, respectively. [2] |
| In vivo | Methods: After 7 days of acclimatization, mice were randomly assigned to groups. Oral administration of sotagliflozin (30 mg/kg/day) began 7 days prior to surgery using a vehicle solution of 10% DMSO + 90% corn oil at a volume of 10 mL/kg/day. Myocardial infarction (MI) or sham surgery was performed on day 8. Following a 3-day postoperative recovery period, drug administration continued for 25 days, totaling approximately 5 weeks of treatment. Results: Sotagliflozin treatment significantly improved MI-induced cardiac dysfunction, with recovery of EF, FS, and other parameters, and markedly reduced myocardial fibrosis area and infarct size. [1] |
| Synonyms | LX-4211, LP-802034 |
| Molecular Weight | 424.94 |
| Formula | C21H25ClO5S |
| Cas No. | 1018899-04-1 |
| Smiles | CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1 |
| Relative Density. | 1.37 g/cm3 (Predicted) |
| Storage | Keep away from moisture,Keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 262.5 mg/mL (617.73 mM), Sonication is recommended.  H2O: < 1 mg/mL (insoluble or slightly soluble) Ethanol: 14 mg/mL (32.95 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | |||||||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Keywords
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Related Tags: Sotagliflozin chemical structure | Sotagliflozin in vivo | Sotagliflozin in vitro | Sotagliflozin formula | Sotagliflozin molecular weight
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