Shopping Cart

Your shopping cart is currently empty

Sotagliflozin

Name: Sotagliflozin
Brand: TargetMol
SKU: T3547
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

😃Good

Hot

Catalog No. T3547Cas No. 1018899-04-1

Alias LX-4211, LP-802034

Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.

Sotagliflozin

😃Good

Hot

Purity: 99.86%

Catalog No. T3547Alias LX-4211, LP-802034Cas No. 1018899-04-1

Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
2 mg	$52	In Stock	In Stock
5 mg	$89	In Stock	In Stock
10 mg	$133	In Stock	In Stock
25 mg	$261	In Stock	In Stock
50 mg	$397	In Stock	In Stock
100 mg	$590	In Stock	In Stock
500 mg	$1,260	-	In Stock
1 mL x 10 mM (in DMSO)	$90	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.86%

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description	Sotagliflozin (LP-802034) is an orally bioavailable inhibitor of the sodium-glucose co-transporter subtype 1 (SGLT1) and 2 (SGLT2), with potential antihyperglycemic activity.
Targets&IC50	SGLT1:62 nM (mouse), SGLT2:0.6 nM (mouse), SGLT1:36 nM (human), SGLT2:1.8 nM (human)
In vitro	LX4211 inhibits [14C]AMG uptake with IC50 of 62.0 nM for mouse SGLT1 and 0.6 nM for mouse SGLT2, respectively. [2]
In vivo	In mice, LX4211 (60 mg/kg, p.o.) reduces intestinal glucose absorption by inhibiting SGLT1, resulting in net increases in GLP-1 and PYY release and decreases in GIP release and blood glucose excursions. [2] In nonobese diabetes-prone mice with type 1 diabetes, Sotagliflozin (30 mg/kg) significantly improves glycemic control, without increasing the rate of hypoglycemia measurements. [3]
Synonyms	LX-4211, LP-802034

Chemical Properties

Molecular Weight	424.94
Formula	C₂₁H₂₅ClO₅S
Cas No.	1018899-04-1
Smiles	CCOc1ccc(Cc2cc(ccc2Cl)[C@@H]2O[C@H](SC)[C@@H](O)[C@H](O)[C@H]2O)cc1
Relative Density.	1.37 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 262.5 mg/mL (617.73 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 14 mg/mL (32.95 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3533 mL	11.7664 mL	23.5327 mL	117.6637 mL
5 mM	0.4707 mL	2.3533 mL	4.7065 mL	23.5327 mL
10 mM	0.2353 mL	1.1766 mL	2.3533 mL	11.7664 mL
20 mM	0.1177 mL	0.5883 mL	1.1766 mL	5.8832 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0471 mL	0.2353 mL	0.4707 mL	2.3533 mL
100 mM	0.0235 mL	0.1177 mL	0.2353 mL	1.1766 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc