Powder: -20°C for 3 years | In solvent: -80°C for 1 year
HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivative of ellagic acid, which induces apoptosis in neuronal cells. HBDDE is a derivative of ellagic acid and induces apoptosis in neuronal cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 350.00 | |
5 mg | In stock | $ 828.00 | |
10 mg | In stock | $ 1,130.00 | |
25 mg | In stock | $ 1,590.00 | |
50 mg | In stock | $ 1,980.00 | |
100 mg | In stock | $ 2,500.00 | |
500 mg | In stock | $ 4,900.00 |
Description | HBDDE is a selective model inhibitor of the isoenzymes PKCα and PKCγ with IC 50 s of 43 μM and 50 μM, respectively.HBDDE has a higher affinity for PKCα/PKCγ than the PKCδ, PKCβI, and PKCβII isoenzymes.HBDDE is a derivative of ellagic acid, which induces apoptosis in neuronal cells. HBDDE is a derivative of ellagic acid and induces apoptosis in neuronal cells. |
Targets&IC50 | PKCα:43 μM (IC50), PKCγ:50 μM (IC50) |
In vitro | HBDDE (50 μM; 5 h; Cerebellar granule cells) leads to a substantial reduction in cell viability by approximately 70%. Additionally, HBDDE demonstrates a notable augmentation in caspase-3 activity.[1] |
Molecular Weight | 338.31 |
Formula | C16H18O8 |
CAS No. | 154675-18-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.5 mg/mL (13.3 mM)
H2O: 0.9 mg/mL (2.7 mM)
Ethanol: 0.9 mg/mL (2.7 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
HBDDE 154675-18-0 Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling PKC inhibitor inhibit