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Nitrocefin

Name: Nitrocefin
Brand: TargetMol
SKU: T19709
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19709Cas No. 41906-86-9

Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria.

Nitrocefin

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Purity: 98.22%

Catalog No. T19709Cas No. 41906-86-9

Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$66	In Stock	In Stock
5 mg	$141	In Stock	In Stock
10 mg	$241	In Stock	In Stock
25 mg	$457	In Stock	In Stock
50 mg	$587	In Stock	In Stock
100 mg	$842	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.22%

Appearance:Solid

Resource Download

COA HPLC HNMR

Product Introduction

Nitrocefin AI Summary

Nitrocefin exhibits bioactivity primarily as a beta-lactamase inhibitor, showing significant inhibitory effects across various bacterial beta-lactamase enzymes, including those from Citrobacter freundii, Escherichia coli, Pseudomonas aeruginosa, and Klebsiella pneumoniae. The compound displays diverse kinetic parameters, with Km values ranging from 9000.0 nM to 1,300,000 nM and Kcat values from 0.7 /s to 2794.0 /s, depending on the specific enzyme tested. Key data points include a Km value of 32000.0 nM and a Kcat value of 48.0 /s for Citrobacter freundii PER2 beta-lactamase, and a Ki value of 36600.0 nM for recombinant SPM-1. The varied Kcat/Km ratios indicate different levels of enzymatic efficiency, suggesting Nitrocefin's potential as a broad-spectrum beta-lactamase inhibitor. Notably, the compound exhibited an activity level of 224.0% compared to cephalothin and varying effectiveness relative to other antibiotics like cephaloridine. The compound also displayed bioactivity against metallo-beta-lactamases, including VIM-11, VIM-2, and CphA, as well as non-beta-lactamase targets such as human NAPE-PLD with an IC50 of 100000.0 nM. Overall, these findings highlight Nitrocefin's potential for further development in combating antibiotic-resistant bacterial infections..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Nitrocefin is an antibiotic. It being sensitive to hydrolysis by all lactamases produced by gram-positive and gram-negative bacteria.

Chemical Properties

Molecular Weight	516.5
Formula	C₂₁H₁₆N₄O₈S₂
Cas No.	41906-86-9
Smiles	OC(=O)C1=C(CS[C@@H]2[C@H](NC(=O)Cc3cccs3)C(=O)N12)\C=C\c1ccc(cc1[N+]([O-])=O)[N+]([O-])=O
Relative Density.	1.67g/cm3

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 255 mg/mL (493.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9361 mL	9.6805 mL	19.3611 mL	96.8054 mL
5 mM	0.3872 mL	1.9361 mL	3.8722 mL	19.3611 mL
10 mM	0.1936 mL	0.9681 mL	1.9361 mL	9.6805 mL
20 mM	0.0968 mL	0.4840 mL	0.9681 mL	4.8403 mL
50 mM	0.0387 mL	0.1936 mL	0.3872 mL	1.9361 mL
100 mM	0.0194 mL	0.0968 mL	0.1936 mL	0.9681 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc