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cIAP1 ligand 1

Name: cIAP1 ligand 1
Brand: TargetMol
SKU: T17870
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17870Cas No. 2095244-42-9

Alias E3 ligase Ligand 12

cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used in conjunction with androgen receptor ligands for the development of protein degradation agents that can be used in the study of prostate cancer.

cIAP1 ligand 1

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Purity: 98.77%

Catalog No. T17870Alias E3 ligase Ligand 12Cas No. 2095244-42-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$42	-	In Stock
5 mg	$98	-	In Stock
10 mg	$143	-	In Stock
25 mg	$289	-	In Stock
50 mg	$455	-	In Stock
100 mg	$728	-	In Stock
200 mg	$982	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.77%

Appearance:Solid

Color:White to Orange

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used in conjunction with androgen receptor ligands for the development of protein degradation agents that can be used in the study of prostate cancer.
Synonyms	E3 ligase Ligand 12

Chemical Properties

Molecular Weight	598.75
Formula	C₃₁H₄₂N₄O₆S
Cas No.	2095244-42-9
Smiles	C[C@H](N(C)C(=O)OC(C)(C)C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1cccc(O)c1
Relative Density.	1.245 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (133.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6701 mL	8.3507 mL	16.7015 mL	83.5073 mL
5 mM	0.3340 mL	1.6701 mL	3.3403 mL	16.7015 mL
10 mM	0.1670 mL	0.8351 mL	1.6701 mL	8.3507 mL
20 mM	0.0835 mL	0.4175 mL	0.8351 mL	4.1754 mL
50 mM	0.0334 mL	0.1670 mL	0.3340 mL	1.6701 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8351 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc