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cIAP1 ligand 1

Name: cIAP1 ligand 1
Brand: TargetMol
SKU: T17870
Price: 42 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: E3 ligase Ligand 12) Copy Product Info

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Synonyms: E3 ligase Ligand 12

Catalog No. T17870 Copy Product Info

Purity: 98.77%

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cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used in conjunction with androgen receptor ligands for the development of protein degradation agents that can be used in the study of prostate cancer.

Cas No. 2095244-42-9

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Pack Size	Price	USA Stock	Global Stock
1 mg	$42	-	In Stock
5 mg	$98	-	In Stock
10 mg	$143	-	In Stock
25 mg	$289	-	In Stock
50 mg	$455	-	In Stock
100 mg	$728	-	In Stock
200 mg	$982	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:98.77%

Appearance:Solid

Color:White to Orange

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COA HNMR HPLC

Product Introduction

Bioactivity

Description	cIAP1 ligand 1 (E3 ligase Ligand 12) is an apoptotic protein ligand based on the LCL161 derivative that recruits IAP ubiquitin ligases to degrade target proteins, and can be used in conjunction with androgen receptor ligands for the development of protein degradation agents that can be used in the study of prostate cancer.
Synonyms	E3 ligase Ligand 12

Chemical Properties

Molecular Weight	598.75
Formula	C₃₁H₄₂N₄O₆S
Cas No.	2095244-42-9
Smiles	C[C@H](N(C)C(=O)OC(C)(C)C)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1c1nc(cs1)C(=O)c1cccc(O)c1
Relative Density.	1.245 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Store under nitrogen Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (133.61 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.6701 mL	8.3507 mL	16.7015 mL	83.5073 mL
5 mM	0.3340 mL	1.6701 mL	3.3403 mL	16.7015 mL
10 mM	0.1670 mL	0.8351 mL	1.6701 mL	8.3507 mL
20 mM	0.0835 mL	0.4175 mL	0.8351 mL	4.1754 mL
50 mM	0.0334 mL	0.1670 mL	0.3340 mL	1.6701 mL
100 mM	0.0167 mL	0.0835 mL	0.1670 mL	0.8351 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc