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Sepantronium bromide

Name: Sepantronium bromide
Brand: TargetMol
SKU: T2111
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2111Cas No. 781661-94-7

Alias YM155

Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.

Sepantronium bromide

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Purity: 99.85%

Catalog No. T2111Alias YM155Cas No. 781661-94-7

Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$33	In Stock	In Stock
5 mg	$50	In Stock	In Stock
10 mg	$72	In Stock	In Stock
25 mg	$151	In Stock	In Stock
50 mg	$270	In Stock	In Stock
100 mg	$441	In Stock	In Stock
500 mg	$980	-	In Stock
1 mL x 10 mM (in DMSO)	$50	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sepantronium bromide (YM155) is a small-molecule proapoptotic agent with potential antineoplastic activity.
Targets&IC50	Survivin:0.54 nM
In vitro	Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice.
In vivo	Subcutaneous injection of 3 and 10 mg/kg YM155 into prostate transplantation tumors showed that YM155 completely inhibited the tumor growth of PC-3 with no decrease in weight and no decrease in blood cell count. Moreover, 5 mg/kg YM155 showed 80% tumor inhibition in PC-3 ectopic graft tumors.The combination of YM155 and γ-radiation showed high antitumor activity against H460 or Calu6 xenografts in nude mice.
Kinase Assay	Promoter-luciferase reporter assay: A 2,767-bp sequence of human survivin gene promoter is isolated from human genomic DNA by PCR using Pyrobest polymerase and the following primers: 5
Cell Research	Cells are seeded in 96-well plates at a density of 5-40 × 103. YM155 is dissolved in DMSO and added to cells for 48 hours. Then the cell count is determined by sulforhodamine B assay. (Only for Reference)
Synonyms	YM155

Chemical Properties

Molecular Weight	443.26
Formula	C₂₀H₁₉BrN₄O₃
Cas No.	781661-94-7
Smiles	[Br-].COCCn1c(C)[n+](Cc2cnccn2)c2c1C(=O)c1ccccc1C2=O
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 82 mg/mL (184.99 mM), Sonication is recommended.

Ethanol: 6 mg/mL (13.54 mM), Sonication is recommended.

DMSO: 48 mg/mL (108.29 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1 mg/mL (2.26 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.2560 mL	11.2801 mL	22.5601 mL	112.8006 mL
5 mM	0.4512 mL	2.2560 mL	4.5120 mL	22.5601 mL
10 mM	0.2256 mL	1.1280 mL	2.2560 mL	11.2801 mL

DMSO/H2O

	1mg	5mg	10mg	50mg
20 mM	0.1128 mL	0.5640 mL	1.1280 mL	5.6400 mL
50 mM	0.0451 mL	0.2256 mL	0.4512 mL	2.2560 mL
100 mM	0.0226 mL	0.1128 mL	0.2256 mL	1.1280 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc