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Estradiol 3-sulfamate

Name: Estradiol 3-sulfamate
Brand: TargetMol
SKU: T11235
Price: 126 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T11235Cas No. 172377-52-5

Alias ES-J 995, E2MATE, BLE 00084

Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer.

Estradiol 3-sulfamate

🥰Excellent

Purity: 97.99%

Catalog No. T11235Alias ES-J 995, E2MATE, BLE 00084Cas No. 172377-52-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$126	In Stock	In Stock
5 mg	$297	In Stock	In Stock
10 mg	$476	In Stock	In Stock
25 mg	$953	In Stock	In Stock
50 mg	$1,480	In Stock	In Stock
100 mg	$1,980	In Stock	In Stock
200 mg	$2,670	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$327	In Stock	In Stock

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Expected start date of shipmentUSA Warehouse [1-2 days] Global Warehouse [5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:97.99%

ee:100%

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COA CSFC HNMR LCMS

Product Introduction

Bioactivity

Description	Estradiol 3-sulfamate (BLE 00084) is an orally active and highly potent steroidal estrone sulfatase (ES) inhibitor.Estradiol 3-sulfamate has a K(i) value of 73 nM for ES in human placental microsomes and can be used in the study of breast cancer.
Targets&IC50	estrone sulfatase:133 nM(Ki), estrone sulfatase:251 nM
In vitro	Compared to the lead compound EMATE, Estradiol 3-sulfamate exhibits superior inhibitory activity against estrone sulfatase[1].
In vivo	Estradiol 3-sulfamate readily transforms into its metabolite EMATE in the gut, making it a more effective STS inhibitor[2].
Synonyms	ES-J 995, E2MATE, BLE 00084

Chemical Properties

Molecular Weight	351.46
Formula	C₁₈H₂₅NO₄S
Cas No.	172377-52-5
Smiles	[H][C@@]12CC[C@H](O)[C@@]1(C)CC[C@]1([H])c3ccc(OS(N)(=O)=O)cc3CC[C@@]21[H]
Relative Density.	1.319 g/cm3 (Predicted)
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (142.26 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8453 mL	14.2264 mL	28.4527 mL	142.2637 mL
5 mM	0.5691 mL	2.8453 mL	5.6905 mL	28.4527 mL
10 mM	0.2845 mL	1.4226 mL	2.8453 mL	14.2264 mL
20 mM	0.1423 mL	0.7113 mL	1.4226 mL	7.1132 mL
50 mM	0.0569 mL	0.2845 mL	0.5691 mL	2.8453 mL
100 mM	0.0285 mL	0.1423 mL	0.2845 mL	1.4226 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc