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4-Hydroxymethylpyrazole

Catalog No. T66965 Copy Product Info
Purity: 99.93%
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4-Hydroxymethylpyrazole is the main primary metabolite of formomizole formed in the process of liver oxidation. The plasma level increases with the increase of dosage of formomizole, but the half-life is relatively short. 4-Hydroxymethylpyrazole has a certain inhibitory effect on alcohol dehydrogenase (ADH) in humans and monkeys, but its inhibitory effect is obviously lower than that of Fomepizole.

4-Hydroxymethylpyrazole

Copy Product Info
🥰Excellent
Catalog No. T66965

4-Hydroxymethylpyrazole is the main primary metabolite of formomizole formed in the process of liver oxidation. The plasma level increases with the increase of dosage of formomizole, but the half-life is relatively short. 4-Hydroxymethylpyrazole has a certain inhibitory effect on alcohol dehydrogenase (ADH) in humans and monkeys, but its inhibitory effect is obviously lower than that of Fomepizole.

4-Hydroxymethylpyrazole
Cas No. 25222-43-9
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Pack SizePriceUSA StockGlobal StockQuantity
200 mg$37-In Stock
500 mg$58-In Stock
1 g$83-In Stock
1 mL x 10 mM (in DMSO)$30-In Stock
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:99.93%
Appearance:Solid
Color:White
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Product Introduction

Bioactivity
Description
4-Hydroxymethylpyrazole is the main primary metabolite of formomizole formed in the process of liver oxidation. The plasma level increases with the increase of dosage of formomizole, but the half-life is relatively short. 4-Hydroxymethylpyrazole has a certain inhibitory effect on alcohol dehydrogenase (ADH) in humans and monkeys, but its inhibitory effect is obviously lower than that of Fomepizole.
Chemical Properties
Molecular Weight98.11
FormulaC4H6N2O
Cas No.25222-43-9
SmilesOCC1=CNN=C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 100.00 mg/mL (1019.26 mM), Sonication is recommended.
H2O: 100.00 mg/mL (1019.26 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM10.1926 mL50.9632 mL101.9264 mL509.6320 mL
5 mM2.0385 mL10.1926 mL20.3853 mL101.9264 mL
10 mM1.0193 mL5.0963 mL10.1926 mL50.9632 mL
20 mM0.5096 mL2.5482 mL5.0963 mL25.4816 mL
50 mM0.2039 mL1.0193 mL2.0385 mL10.1926 mL
100 mM0.1019 mL0.5096 mL1.0193 mL5.0963 mL
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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