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PI3K/mTOR Inhibitor-2

Name: PI3K/mTOR Inhibitor-2
Brand: TargetMol
SKU: T12459
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12459Cas No. 1848242-58-9

PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively. PI3K/mTOR Inhibitor-2 demonstrates antitumor activity.

PI3K/mTOR Inhibitor-2

🥰Excellent

Purity: 96.16%

Catalog No. T12459Cas No. 1848242-58-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	-	In Stock
5 mg	$148	-	In Stock
10 mg	$238	-	In Stock
25 mg	$397	-	In Stock
50 mg	$568	-	In Stock
100 mg	$768	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$155	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:96.16%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively. PI3K/mTOR Inhibitor-2 demonstrates antitumor activity.
Targets&IC50	PI3Kγ:1 nM, PI3Kδ:16 nM, PI3Kβ:34 nM, mTOR:4.7 nM, PI3Kα:3.4 nM
In vitro	PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile[1].
In vivo	PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model[1].

Chemical Properties

Molecular Weight	478.86
Formula	C₂₀H₁₃ClF₂N₄O₄S
Cas No.	1848242-58-9
Smiles	COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (114.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0883 mL	10.4415 mL	20.8829 mL	104.4147 mL
5 mM	0.4177 mL	2.0883 mL	4.1766 mL	20.8829 mL
10 mM	0.2088 mL	1.0441 mL	2.0883 mL	10.4415 mL
20 mM	0.1044 mL	0.5221 mL	1.0441 mL	5.2207 mL
50 mM	0.0418 mL	0.2088 mL	0.4177 mL	2.0883 mL
100 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc