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PI3K/mTOR Inhibitor-2

Name: PI3K/mTOR Inhibitor-2
Brand: TargetMol
SKU: T12459
Price: 53 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T12459Cas No. 1848242-58-9

PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively. PI3K/mTOR Inhibitor-2 demonstrates antitumor activity.

PI3K/mTOR Inhibitor-2

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Purity: 96.16%

Catalog No. T12459Cas No. 1848242-58-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$53	-	In Stock
5 mg	$148	-	In Stock
10 mg	$238	-	In Stock
25 mg	$397	-	In Stock
50 mg	$568	-	In Stock
100 mg	$768	-	In Stock
200 mg	$987	-	In Stock
1 mL x 10 mM (in DMSO)	$155	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:96.16%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16.1, and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ, and mTOR, respectively. PI3K/mTOR Inhibitor-2 demonstrates antitumor activity.
Targets&IC50	PI3Kδ:16 nM, PI3Kβ:34 nM, PI3Kα:3.4 nM, PI3Kγ:1 nM, mTOR:4.7 nM
In vitro	PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile[1].
In vivo	PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model[1].

Chemical Properties

Molecular Weight	478.86
Formula	C₂₀H₁₃ClF₂N₄O₄S
Cas No.	1848242-58-9
Smiles	COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 55 mg/mL (114.86 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0883 mL	10.4415 mL	20.8829 mL	104.4147 mL
5 mM	0.4177 mL	2.0883 mL	4.1766 mL	20.8829 mL
10 mM	0.2088 mL	1.0441 mL	2.0883 mL	10.4415 mL
20 mM	0.1044 mL	0.5221 mL	1.0441 mL	5.2207 mL
50 mM	0.0418 mL	0.2088 mL	0.4177 mL	2.0883 mL
100 mM	0.0209 mL	0.1044 mL	0.2088 mL	1.0441 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc