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TRPA1 agonist-3

Name: TRPA1 agonist-3
Brand: TargetMol
SKU: T214074
Rating: 4.5 (1 reviews)

Catalog No. T214074 Copy Product Info

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TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, exhibiting EC50 values of 50.05 μM for human TRPA1 and 314.04 μM for mouse TRPA1 in HEK-293T cells. This compound does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. Additionally, TRPA1 agonist-3 alleviates inflammatory pain in mice through channel desensitization mechanisms.

TRPA1 agonist-3

Copy Product Info

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Catalog No. T214074

TRPA1 agonist-3

Cas No. 3083086-77-2

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	TRPA1 agonist-3 is a selective and orally active TRPA1 agonist, exhibiting EC50 values of 50.05 μM for human TRPA1 and 314.04 μM for mouse TRPA1 in HEK-293T cells. This compound does not activate hTRPV1, mTRPV2, hTRPV3, hTRPV4, hTRPC6, or hTRPM8 channels. Additionally, TRPA1 agonist-3 alleviates inflammatory pain in mice through channel desensitization mechanisms.
Targets&IC50	TRPA1:50.50 μM (EC50, human)
In vitro	TRPA1 agonist-3 (compound NMTA) at a concentration of 50 μM for 24 hours activates hTRPA1 channels in HEK-293T cells in a concentration-dependent manner, resulting in calcium influx. Additionally, TRPA1 agonist-3 exerts analgesic effects through the desensitization mechanism of TRPA1.
In vivo	TRPA1 agonist-3 (compound NMTA) administered orally at 10-40 mg/kg as a single dose, alleviates inflammation-induced pain in male C57BL/6J mice, which is caused by a plantar injection of CFA (Complete Freund’s Adjuvant) (20 μL). It exhibits selective desensitization of TRPA1 without directly inhibiting heat-sensitive channels in these mice. Furthermore, TRPA1 agonist-3 demonstrates antihyperalgesic effects on cold-induced pain in male C57BL/6J mice.

Chemical Properties

Molecular Weight	262.37
Formula	C₁₄H₁₈N₂OS
Cas No.	3083086-77-2
Smiles	N1=C(SC=C1C=2C=CC(=CC2)C)NCCCOC

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc