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Anti-HTR2C Antibody (5H488) is a Rabbit antibody targeting HTR2C. Anti-HTR2C Antibody (5H488) can be used in WB,IHC.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $297 | 7-10 days | |
100 μL | $496 | 7-10 days |
Description | Anti-HTR2C Antibody (5H488) is a Rabbit antibody targeting HTR2C. Anti-HTR2C Antibody (5H488) can be used in WB,IHC. |
Synonyms | Serotonin receptor 2C, Serotonin 5-HT-2C receptor, serotonin 2c receptor, serotonin 1c receptor, HTR2C, Htr1c, 5-hydroxytryptamine(serotonin) receptor 2C, G protein-coupled, 5-hydroxytryptamine receptor 2C, 5-hydroxytryptamine receptor 1C, 5Hydroxytryptamine 2C receptor, 5-HTR2C, 5HTR2C, 5-HT-2C, 5-HT2C, 5HT2C, 5-HT-1C receptor, 5-HT1C, 5 Hydroxytryptamine 2C receptor |
Ig Type | IgG |
Reactivity | Human,Mouse,Rat |
Verified Activity | 1. Western blot analysis of 5HT2C Receptor on A431 (1) AND K562 (2) lysates using anti-5HT2C Receptor antibody at 1/1,000 dilution. 2. Immunohistochemical analysis of paraffin-embedded mouse brain tissue using anti-5HT2C Receptor antibody. Counter stained with hematoxylin. |
Application | |
Recommended Dose | WB: 1:500-2000; IHC: 1:50-200 |
Antibody Type | Monoclonal |
Host Species | Rabbit |
Construction | Recombinant Antibody |
Purification | ProA affinity purified |
Appearance | Liquid |
Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
Research Background | G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including ergot alkaloid derivatives, 1-2,5,-dimethoxy-4-iodophenyl-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Regulates neuronal activity via the activation of short transient receptor potential calcium channels in the brain, and thereby modulates the activation of pro-opiomelacortin neurons and the release of CRH that then regulates the release of corticosterone. |
Conjucates | Unconjugated |
Immunogen | Recombinant Protein |
Uniprot ID |
Molecular Weight | Theoretical: 70 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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