ALK-1 Protein, Human, Recombinant (His)

Name: ALK-1 Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01168
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: TSR-I, SKR3, ORW2, HHT2, HHT, ALK-1, ALK1, ACVRLK1, ACVRL1, activin A receptor type II-like 1) Copy Product Info

Synonyms: TSR-I, SKR3, ORW2, HHT2, HHT, ALK-1, ALK1, ACVRLK1, ACVRL1, activin A receptor type II-like 1

Catalog No. TMPY-01168 Copy Product Info

Purity: 98.7%

ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.

Pack Size	Price	USA Stock	Global Stock
5 µg	$41	-	In Stock
10 µg	$63	-	In Stock
20 µg	$100	-	In Stock
50 µg	$192	-	In Stock
100 µg	$320	-	In Stock
200 µg	$567	7-10 days	7-10 days
500 µg	$1,200	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:98.7%

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to inhibit BMP9 induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 50-200 ng/mL in the presence of 2 ng/mL of recombinant human BMP9.
Description	ALK-1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 12.3 kDa and the accession number is A0A0S2Z310.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P37023
Construction	A DNA sequence encoding the the extracellular domain of human ALK1 (NP_000011.2) (Met 1-Gln 118) was fused with a polyhistide tag at the C-terminus. Predicted N terminal: Asp 22
Protein Purity	> 92 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	Reconstituted with sterile deionized water to 0.25 mg/mL. Reconstitution conditions may vary depending on the lot.
Synonyms	TSR-I, SKR3, ORW2, HHT2, HHT, ALK-1, ALK1, ACVRLK1, ACVRL1, activin A receptor type II-like 1
Research Background	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.

Chemical Properties

Molecular Weight

12.3 kDa (predicted); 27 kDa (reducing condition, due to glycosylation)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.