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Anti-Siglec-10 Polyclonal Antibody
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Catalog No. TMAB-01687
Alias SLG2, SIGLEC10, PRO940, MGC126774
Anti-Siglec-10 Polyclonal Antibody is a Rabbit antibody targeting Siglec-10. Anti-Siglec-10 Polyclonal Antibody can be used in ELISA,WB.
Anti-Siglec-10 Polyclonal Antibody
Anti-Siglec-10 Polyclonal Antibody
😃Good
Catalog No. TMAB-01687Alias SLG2, SIGLEC10, PRO940, MGC126774
Anti-Siglec-10 Polyclonal Antibody is a Rabbit antibody targeting Siglec-10. Anti-Siglec-10 Polyclonal Antibody can be used in ELISA,WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $221 | 7-10 days | |
| 100 μL | $374 | 7-10 days |
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Siglec-10 Polyclonal Antibody is a Rabbit antibody targeting Siglec-10. Anti-Siglec-10 Polyclonal Antibody can be used in ELISA,WB. |
| Synonyms | SLG2, SIGLEC10, PRO940, MGC126774 |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | Sample: Lane 1: Mouse Spleen tissue lysates Lane 2: Mouse Lung tissue lysates Lane 3: Human HL-60 cell lysates Lane 4: Human K562 cell lysates Lane 5: Human Jurkat cell lysates Primary: Anti-SIGLEC10 (TMAB-01687) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 77 kDa Observed band size: 100 kDa |
| Application | |
| Recommended Dose | WB: 1:500-2000; ELISA: 1:5000-10000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Isoform 1, 2, 3, 4: Cell membrane; Single-pass type I membrane protein. Isoform 5: Secreted. |
| Tissue Specificity | Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform 5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 a |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1 mg/mL |
| Research Background | SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002] |
| Immunogen | KLH conjugated synthetic peptide: human SIGLEC10 |
| Antigen Species | Human |
| Gene Name | SIGLEC10 |
| Gene ID | |
| Protein Name | Sialic acid-binding Ig-like lectin 10 |
| Uniprot ID | |
| Biology Area | Other Cell Types |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. |
| Molecular Weight | Theoretical: 77 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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