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Anti-HDAC3 Antibody (4T61)

Catalog No. TMAB-06934 Copy Product Info
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Anti-HDAC3 Antibody (4T61) is a Rabbit antibody targeting HDAC3. Anti-HDAC3 Antibody (4T61) can be used in WB,ICC/IF.

Anti-HDAC3 Antibody (4T61)

Copy Product Info
🥰Excellent
Catalog No. TMAB-06934

Anti-HDAC3 Antibody (4T61) is a Rabbit antibody targeting HDAC3. Anti-HDAC3 Antibody (4T61) can be used in WB,ICC/IF.

Anti-HDAC3 Antibody
(4T61)
Pack SizePriceUSA StockGlobal StockQuantity
50 μL$2627-10 days7-10 days
100 μL$4737-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-HDAC3 Antibody (4T61) is a Rabbit antibody targeting HDAC3. Anti-HDAC3 Antibody (4T61) can be used in WB,ICC/IF.
Ig Type
IgG
Clone
4T61
Reactivity
Human,Mouse,Rat
Verified Activity
25 μg total protein per lane of various lysates (see on figure) probed with HDAC3 monoclonal antibody, unconjugated (TMAB-06934) at 1: 2000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r. T. for 60 min.
Application
WB
ICC/IF
Recommended Dose
WB: 1:500-2000; ICC/IF: 1:50-200
Antibody Type
Monoclonal
Host SpeciesRabbit
Subcellular LocalizationNucleus.
Tissue SpecificityWidely expressed.
ConstructionRecombinant Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1mg/ml
Research BackgroundHistones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
Antigen Details
Immunogen
A synthesized peptide: human HDAC3
Antigen Species
Human
Gene Name
HDAC3
Gene ID
8841
Protein Name
Histone deacetylase 3
Uniprot ID
O15379
Function
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation.
Chemical Properties
Molecular WeightTheoretical: 47 kDa.
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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