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Anti-RING1 Antibody (1C89)

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Catalog No. TMAC-03607

Anti-RING1 Antibody (1C89) is a Mouse antibody targeting RING1. Anti-RING1 Antibody (1C89) can be used in WB,IHC,FCM.

Anti-RING1 Antibody (1C89)

Anti-RING1 Antibody (1C89)

😃Good
Catalog No. TMAC-03607
Anti-RING1 Antibody (1C89) is a Mouse antibody targeting RING1. Anti-RING1 Antibody (1C89) can be used in WB,IHC,FCM.
Pack SizePriceAvailabilityQuantity
50 μL$2967-10 days
100 μL$4287-10 days
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Product Introduction

Bioactivity
Description
Anti-RING1 Antibody (1C89) is a Mouse antibody targeting RING1. Anti-RING1 Antibody (1C89) can be used in WB,IHC,FCM.
Reactivity
Human
Application
Recommended Dose
WB: 1:500-1000; IHC: 1:100-200; FCM: 1:100-200
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionHybridoma Monoclonal Antibody
PurificationProA affinity purified
AppearanceLiquid
Formulation1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
Research BackgroundIn Drosophila, the Polycomb (PcG) gene family encodes chromatin proteins that are required for the repression of homeotic loci during embryonic development. The human PcG homologues form two distinct multimeric protein complexes, the EED/EZH protein complex and the HPC/HPH protein complex, which have mutually exclusive expression patterns. The HPC/HPH PcG complex contains the human polycomb 2 (HPC2), human polyhomeotic (HPH), Bmi-1 and RING1 proteins. The human RING1 gene, which is proximal to the major histocompatibility complex region on chromosome six, encodes for a protein that contains a RING finger motif, a zinc-binding domain found in many regulatory proteins, but unlike the other human PcG genes, RING1 displays no homology to known Drosophila PcG genes. RING1 strongly represses En-2, the mammalian homolog of the Drosophila engrailed gene, and when overexpressed, it mediates an increase in the expression of proto-oncogenes, such as c-Jun and c-fos. Also, loss of RING1 and Bmi-1 expression correlates with the differentiation of B cells, which suggests a role for RING1 in germinal center development.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein
Antigen Species
Recombinant Protein
Uniprot ID
Chemical Properties
Molecular WeightTheoretical: 50 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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