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Anti-CTHRC1 Antibody (5X662)
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Catalog No. TMAY-01962
Alias collagen triple helix repeat containing 1
Anti-CTHRC1 Antibody (5X662) is a Rabbit antibody targeting CTHRC1. Anti-CTHRC1 Antibody (5X662) can be used in WB,IP.
Anti-CTHRC1 Antibody (5X662)
Anti-CTHRC1 Antibody (5X662)
😃Good
Catalog No. TMAY-01962Alias collagen triple helix repeat containing 1
Anti-CTHRC1 Antibody (5X662) is a Rabbit antibody targeting CTHRC1. Anti-CTHRC1 Antibody (5X662) can be used in WB,IP.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Antigen Details
Chemical Properties
| Description | Anti-CTHRC1 Antibody (5X662) is a Rabbit antibody targeting CTHRC1. Anti-CTHRC1 Antibody (5X662) can be used in WB,IP. |
| Alias | collagen triple helix repeat containing 1 |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 5X662 |
| Reactivity | Human |
| Verified Activity | 1. Anti-CTHRC1 rabbit monoclonal antibody at 1:500 dilution. -Lane A: HepG2 Whole Cell Lysate. -Lane B: HEK293 Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Rabbit IgG H&L (Dylight800) at 1/10000 dilution. -Developed using the Odyssey technique. -Performed under reducing conditions. -Predicted band size:26 kDa. -Observed band size:23 kDa. 2. CTHRC1 was immunoprecipitated using: -Lane A:0.5 mg HepG2 Whole Cell Lysate. -2 µL anti-CTHRC1 rabbit monoclonal antibody and 15 μl of 50 % Protein G agarose. -Primary antibody: -Anti-CTHRC1 rabbit monoclonal antibody, at 1:200 dilution. -Secondary antibody: -Dylight 800-labeled antibody to rabbit IgG (H+L), at 1:5000 dilution. -Developed using the odyssey technique. -Performed under reducing conditions. -Predicted band size: 26 kDa. -Observed band size: 23 kDa |
| Application | WB,IP |
| Recommended Dose | WB: 1:500-1:2000; IP: 1-4 μL/mg of lysate |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CTHRC1 (rh CTHRC1; TMPY-01395; NP_612464.1; Met1-Lys243). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Collagen triple helix repeat-containing protein 1, also known as Protein NMTC1, and CTHRC1, is a secreted protein that is glycosylated and highly conserved from lower chordates to mammals. CTHRC1 expression was not detectable in normal arteries. However, it is transiently expressed in the arterial wall in response to injury where it may contribute to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. A short collagen motif with 12 Gly-X-Y repeats appears to be responsible for trimerization of the CTHRC1 protein and this renders the molecule susceptible to cleavage by collagenase. CTHRC1 overexpression caused a dramatic reduction in collagen type I mRNA and protein levels. Currently available data indicate that Cthrc1 expression in vascular cells regulates transforming growth factor beta responsiveness, thereby impacting transforming growth factor beta target genes, including collagens. Additionally, CTHRC1 increases bone mass as a positive regulator of osteoblastic bone formation and offers an anabolic approach for the treatment of osteoporosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Human CTHRC1 protein (TMPY-01395) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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