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TNIK-IN-1 (Synonyms: TNIK-inhibitor-1, TNIK inhibitor 1)

Name: TNIK-IN-1
Brand: TargetMol
SKU: T26282
Price: 1520 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T26282 Copy Product Info

Purity: 99.01%

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TNIK-IN-1 (Compound 1) is a potent inhibitor of Traf2 and Nck-interacting kinase (TNIK), with an IC50 of 65 nM. TNIK is a pivotal effector in the Wnt/beta-catenin signaling pathway, essential for the maintenance of cancer stem cell properties and cellular proliferation. As a lead molecule based on the 4-phenyl-2-phenylaminopyridine scaffold, TNIK-IN-1 demonstrates significant antitumor activity by blocking TNIK kinase function and disrupting oncogenic signaling cascades, making it a valuable tool for researching Wnt-driven malignancies.

TNIK-IN-1

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Catalog No. T26282

Synonyms TNIK-inhibitor-1, TNIK inhibitor 1

Cas No. 933886-36-3

Pack Size	Price	USA Stock	Global Stock
25 mg	$1,520	-	In Stock
50 mg	$1,980	-	In Stock
100 mg	$2,500	6-8 weeks	6-8 weeks

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:99.01%

Appearance:Solid

Color:Yellow

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	TNIK-IN-1 (Compound 1) is a potent inhibitor of Traf2 and Nck-interacting kinase (TNIK), with an IC50 of 65 nM. TNIK is a pivotal effector in the Wnt/beta-catenin signaling pathway, essential for the maintenance of cancer stem cell properties and cellular proliferation. As a lead molecule based on the 4-phenyl-2-phenylaminopyridine scaffold, TNIK-IN-1 demonstrates significant antitumor activity by blocking TNIK kinase function and disrupting oncogenic signaling cascades, making it a valuable tool for researching Wnt-driven malignancies.
Targets&IC50	TNIK:65 nM
In vitro	In kinase activity assays, TNIK-IN-1 exhibits high affinity for TNIK, functioning as an ATP-competitive inhibitor that binds to the kinase domain. It effectively suppresses the proliferation of tumor cell lines dependent on Wnt signaling, particularly in models of colorectal cancer. Furthermore, as TNIK is involved in cytoskeletal reorganization, TNIK-IN-1 serves as an ideal probe for investigating the molecular drivers of tumor cell migration and invasion [1].
Synonyms	TNIK-inhibitor-1, TNIK inhibitor 1

Chemical Properties

Molecular Weight	395.43
Formula	C₁₉H₁₇N₅O₃S
Cas No.	933886-36-3
Smiles	O=C(N)C=1N=C(SC1NC(=O)C2=CC=C(C=C2)NC(=O)C)NC=3C=CC=CC3
Relative Density.	1.470 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (202.31 mM), Sonication is recommmended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5289 mL	12.6445 mL	25.2889 mL	126.4446 mL
5 mM	0.5058 mL	2.5289 mL	5.0578 mL	25.2889 mL
10 mM	0.2529 mL	1.2644 mL	2.5289 mL	12.6445 mL
20 mM	0.1264 mL	0.6322 mL	1.2644 mL	6.3222 mL
50 mM	0.0506 mL	0.2529 mL	0.5058 mL	2.5289 mL
100 mM	0.0253 mL	0.1264 mL	0.2529 mL	1.2644 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc