keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DOTA-LM3 is a somatostatin receptor (SSTR) antagonist, with LM3 denoting the peptide sequence p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2. It is utilized in the isotopic labeling of tumors for in vivo tracing, notably with 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. The derivative 68Ga-DOTA-LM3 exhibits promising biodistribution, high tumor uptake, efficient tumor retention, and minimal safety concerns, while 177Lu-DOTA-LM3 is applied in research on DOTATOC-negative liver metastases including pancreatic NET and extensive tumor thrombosis [1] [2].
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50 mg | Inquiry | Inquiry |
Description | DOTA-LM3 is a somatostatin receptor (SSTR) antagonist, with LM3 denoting the peptide sequence p-Cl-Phe-cyclo(D-Cys-Tyr-D-4-amino-Phe(carbamoyl)-Lys-Thr-Cys)D-Tyr-NH2. It is utilized in the isotopic labeling of tumors for in vivo tracing, notably with 177Lu-DOTA-LM3 and 68Ga-DOTA-LM3. The derivative 68Ga-DOTA-LM3 exhibits promising biodistribution, high tumor uptake, efficient tumor retention, and minimal safety concerns, while 177Lu-DOTA-LM3 is applied in research on DOTATOC-negative liver metastases including pancreatic NET and extensive tumor thrombosis [1] [2]. |
In vitro | The chemical compound ^177Lu-DOTA-LM3 is well-tolerated. It predominantly localizes in the whole body, kidneys, spleen, and metastatic lesions, resulting in higher average absorbed doses in these organs and tumors [2]. |
Molecular Weight | 1550.16 |
Formula | C69H93ClN16O19S2 |
CAS No. | 1192362-32-5 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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DOTA-LM3 1192362-32-5 inhibitor inhibit