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Anti-CD3 zeta/CD247 Antibody (5W525)
(Synonyms: TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule) Copy Product Info
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Synonyms: TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule
Catalog No. TMAH-00183 Copy Product Info
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Anti-CD3 zeta/CD247 Antibody (5W525) is an antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (5W525) can be used in ELISA,FCM.
Anti-CD3 zeta/CD247 Antibody
(5W525)
(5W525)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $208 | 7-10 days | 7-10 days | |
| 100 μL | $349 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
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Chemical Properties
Stability & Storage
| Description | Anti-CD3 zeta/CD247 Antibody (5W525) is an antibody targeting CD3 zeta/CD247. Anti-CD3 zeta/CD247 Antibody (5W525) can be used in ELISA,FCM. |
| Synonyms | TCRZ, T3Z, IMD25, CD3-ζ, CD3-ZETA, CD3Z, CD3Q, CD3H, CD3 ζ/CD247, CD247 molecule |
| Ig Type | Rabbit IgG |
| Clone | 5W525 |
| Reactivity | Human |
| Application | |
| Recommended Dose | FCM:1:50-1:200. |
| Antibody Type | Monoclonal |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | CD3Z is expressed in normal lymphoid tissue and in peripheral blood mononuclear cells (PBMCs). |
| Construction | Recombinant Antibody |
| Purification | Affinity-chromatography |
| Appearance | Liquid |
| Formulation | Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Research Background | Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme. Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN). |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: Human CD247 |
| Antigen Species | Human |
| Gene Name | CD247 |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Immunology, Stem cells |
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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