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Anti-ABCB11 Polyclonal Antibody
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Catalog No. TMAB-02143
Alias SPGP, PGY4, PFIC-2, PFIC2, EC:7.6.2.-, BSEP, BRIC2, Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCBB_HUMAN, ABC16
Anti-ABCB11 Polyclonal Antibody is a Rabbit antibody targeting ABCB11. Anti-ABCB11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-ABCB11 Polyclonal Antibody
Anti-ABCB11 Polyclonal Antibody
Copy Product Info😃Good
Catalog No. TMAB-02143Alias SPGP, PGY4, PFIC-2, PFIC2, EC:7.6.2.-, BSEP, BRIC2, Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCBB_HUMAN, ABC16
Anti-ABCB11 Polyclonal Antibody is a Rabbit antibody targeting ABCB11. Anti-ABCB11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Anti-ABCB11 Polyclonal Antibody is a Rabbit antibody targeting ABCB11. Anti-ABCB11 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Synonyms | SPGP, PGY4, PFIC-2, PFIC2, EC:7.6.2.-, BSEP, BRIC2, Bile salt export pump, ATP-binding cassette sub-family B member 11, ABCBB_HUMAN, ABC16 |
| Ig Type | IgG |
| Reactivity | Mouse,Rat |
| Verified Activity | 1. Paraformaldehyde-fixed, paraffin embedded (rat liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (ABCB11) Polyclonal Antibody, Unconjugated (TMAB-02143) at 1:300 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. 2. Paraformaldehyde-fixed, paraffin embedded (mouse liver); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15 min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30 min; Antibody incubation with (ABCB11) Polyclonal Antibody, Unconjugated (TMAB-02143) at 1:300 overnight at 4°C, followed by operating according to SP Kit (Rabbit) instructions and DAB staining. |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Membrane; Multi-pass membrane protein. |
| Tissue Specificity | Expressed predominantly, if not exclusively in the liver, where it was further localized to the canalicular microvilli and to subcanalicular vesicles of the hepatocytes by in situ. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human BSEP |
| Antigen Species | Human |
| Gene Name | ABCB11 |
| Gene ID | |
| Protein Name | Bile salt export pump |
| Uniprot ID | |
| Function | Involved in the ATP-dependent secretion of bile salts into the canaliculus of hepatocytes. |
| Molecular Weight | Theoretical: 146 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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