PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

Catalog No. TMPY-02511

PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

PTP alpha/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST)

Catalog No. TMPY-02511

Pack Size	Price	Availability	Quantity
50 μg	$600	7-10 days
500 μg	$3,910	7-10 days

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Product Information

Biological Activity	1. Measured by its ability to bind biotinylated recombinant mouse SRC in a functional ELISA. 2. Measured by its ability to cleave a substrate, pNitrophenyl phosphate (pNPP). The specific activity is >40000 pmol/min/μg.
Description	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	His, GST
Accession Number	P18433-2
Synonyms	R-PTP-α,R-PTP-alpha,RPTPA,PTPRL2,PTPA,PTP α/PTPRA Protein, Human, Recombinant (aa 174-793, His & GST),protein tyrosine phosphatase, receptor type, A,LRP,HPTPα,HPTPalpha,HPTPA,HLPR,HEPTP
Construction	A DNA sequence encoding the human PTPRA isoform 2 (P18433-2) cytoplasmic domain (Ala 174-Lys 793) was fused with the N-terminal polyhistidine-tagged GST tag at the N-terminus. Predicted N terminal: Met
Protein Purity	> 90 % as determined by SDS-PAGE
Molecular Weight	99 kDa (predicted); 90 kDa (reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, pH 7.4, 20% gly, 3 mM DTT.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Shipping with blue ice.
Research Background	PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.