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Eltanexor Z-isomer

Name: Eltanexor Z-isomer
Brand: TargetMol
SKU: T11766
Rating: 4.5 (1 reviews)

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Catalog No. T11766Cas No. 1642300-78-4

Alias KPT-8602 (Z-isomer)

Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.

Eltanexor Z-isomer

😃Good

Catalog No. T11766Alias KPT-8602 (Z-isomer)Cas No. 1642300-78-4

Pack Size	Price	Availability
2 mg	$196	5 days
25 mg	$877	6-8 weeks
50 mg	$1,140	6-8 weeks
100 mg	$1,730	6-8 weeks

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Product Introduction

Bioactivity

Description	Eltanexor Z-isomer exhibits different inhibitory effects on Z138, MM15, 3T3 cell lines, with IC50s of 100 nM-50 μM, < 100 nM, > 30 μM, respectively.Eltanexor Z-isomer is the less active isomer of KPT-8602. KPT-8602 is a potent CRM1 inhibitor.
Synonyms	KPT-8602 (Z-isomer)

Chemical Properties

Molecular Weight	428.29
Formula	C₁₇H₁₀F₆N₆O
Cas No.	1642300-78-4
Relative Density.	1.57 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (116.74 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3349 mL	11.6743 mL	23.3487 mL	116.7433 mL
5 mM	0.4670 mL	2.3349 mL	4.6697 mL	23.3487 mL
10 mM	0.2335 mL	1.1674 mL	2.3349 mL	11.6743 mL
20 mM	0.1167 mL	0.5837 mL	1.1674 mL	5.8372 mL
50 mM	0.0467 mL	0.2335 mL	0.4670 mL	2.3349 mL
100 mM	0.0233 mL	0.1167 mL	0.2335 mL	1.1674 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc