Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | Inquiry | $ 498.00 | |
10 mg | Inquiry | $ 872.00 |
Description | BMS-1166-N-piperidine-COOH is a chemical compound that functions as the BMS-1166-based moiety. It binds to the E3 ligase ligand through a linker, leading to the formation of PROTAC PD-1/PD-L1 degrader-1, which facilitates the degradation of PD-1/PD-L1. BMS-1166 demonstrates potent inhibition of PD-1/PD-L1 interaction, with an IC 50 of 1.4 nM. By antagonizing the inhibitory effect of the PD-1/PD-L1 immune checkpoint on T cell activation, BMS-1166 promotes T cell activation. |
Molecular Weight | 639.15 |
Formula | C37H35ClN2O6 |
CAS No. | 2447066-00-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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BMS-1166-N-piperidine-COOH 2447066-00-2 BMS 1166 N piperidine COOH BMS1166NpiperidineCOOH inhibitor inhibit