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BMY-14802
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Catalog No. T67739Cas No. 105565-56-8
Alias alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
BMY-14802
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Purity: 99.84%
Catalog No. T67739Alias alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanolCas No. 105565-56-8
BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $30 | In Stock | In Stock | |
| 5 mg | $48 | In Stock | In Stock | |
| 10 mg | $83 | In Stock | In Stock | |
| 25 mg | $167 | In Stock | In Stock | |
| 50 mg | $273 | In Stock | In Stock | |
| 100 mg | $403 | In Stock | In Stock | |
| 200 mg | $573 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $53 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.84%
Appearance:Solid
Color:Yellow
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Product Introduction
BMY-14802 AI Summary
BMY-14802 exhibits multiple bioactivities, particularly targeting sigma opioid receptors, dopamine receptors, and serotonin receptors. It shows binding affinity towards sigma opioid receptor type 1 with Ki values ranging from 60.0 to 265.0 nM, and towards sigma opioid receptor type 2 with Ki values between 164.0 nM and 391.0 nM, evidencing moderate selectivity for sigma 1 over sigma 2 with a selectivity ratio of 1.5. BMY-14802 also demonstrates notable affinity towards dopamine receptor D2 and serotonin 5-HT2 receptors, with IC50 values of 2431.0 nM and 410.0 nM, respectively, and minimal effects on dopamine receptors D1. In functional tests, it shows significant potency in behavioral models, reflecting its potential neuroprotective and psychoactive effects, including inhibition of mescaline-induced activity and apomorphine-induced stereotypy. Additionally, BMY-14802 reveals moderate histamine H1 and H2 receptor affinities and shows antiviral potential against SARS-CoV-2. Finally, it exhibits inhibitory activity against human HDAC6 enzymes, albeit with modest inhibition percentages..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | BMY-14802 (alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol) is a selective and orally active sigma-1 antagonist with an IC50 of 112 nM. |
| Synonyms | alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazine butanol |
| Molecular Weight | 348.39 |
| Formula | C18H22F2N4O |
| Cas No. | 105565-56-8 |
| Smiles | OC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)cc1 |
| Relative Density. | 1.256 g/cm3 (Predicted) |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 4.5 mg/mL (12.92 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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