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BCX 1470 methanesulfonate

Name: BCX 1470 methanesulfonate
Brand: TargetMol
SKU: T13567
Rating: 4.5 (1 reviews)

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Catalog No. T13567Cas No. 217099-44-0

BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), exhibiting 3.4- and 200-fold greater efficacy than trypsin, respectively.

BCX 1470 methanesulfonate

😃Good

Catalog No. T13567Cas No. 217099-44-0

BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), exhibiting 3.4- and 200-fold greater efficacy than trypsin, respectively.

Pack Size	Price	Availability
25 mg	$1,080	1-2 weeks
50 mg	$1,410	1-2 weeks
100 mg	$2,140	1-2 weeks

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Product Introduction

Bioactivity

Description	BCX 1470 methanesulfonate inhibits the esterolytic activity of factor D and C1s (IC50: 96 nM and 1.6 nM), exhibiting 3.4- and 200-fold greater efficacy than trypsin, respectively.
Targets&IC50	C1s:1.6 nM , Trypsin:326 nM , FD:96 nM
In vitro	BCX 1470 methanesulfonate is an inhibitor serine protease. BCX 1470 blocks the esterolytic and hemolytic activities of the complement enzymes Cls and factor D in vitro.
In vivo	BCX 1470 methanesulfonate blocked the development of RPA-induced edema in the rat.

Chemical Properties

Molecular Weight	398.48
Formula	C₁₅H₁₄N₂O₅S₃
Cas No.	217099-44-0
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 33.33 mg/mL (83.64 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5095 mL	12.5477 mL	25.0954 mL	125.4768 mL
5 mM	0.5019 mL	2.5095 mL	5.0191 mL	25.0954 mL
10 mM	0.2510 mL	1.2548 mL	2.5095 mL	12.5477 mL
20 mM	0.1255 mL	0.6274 mL	1.2548 mL	6.2738 mL
50 mM	0.0502 mL	0.2510 mL	0.5019 mL	2.5095 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc