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K6PC-5

Name: K6PC-5
Brand: TargetMol
SKU: T27710
Price: 34 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T27710Cas No. 756875-51-1

Alias K6PC5, K6PC 5

K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.

K6PC-5

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Purity: 99.9%

Catalog No. T27710Alias K6PC5, K6PC 5Cas No. 756875-51-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$34	In Stock	In Stock
5 mg	$80	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$472	In Stock	In Stock
100 mg	$693	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$89	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.9%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	K6PC-5 is a ceramide derivative that acts as an activator of sphingosine kinase 1 (SPHK1), inducing a swift and temporary rise in intracellular calcium levels. With its potential applications in skin diseases associated with abnormal keratinocyte function, as well as in studies on neurodegeneration and virus infection, K6PC-5 presents a promising compound for research purposes.
In vitro	K6PC-5 (1-10 μM; 24 h) increases involucrin and loricrin levels in a dose-dependent manner in normal human epidermal keratinocytes (NHEKs), promotes differentiation and proliferation of keratinocytes via intracellular Ca2+ signaling, and stimulates the phosphorylation of p42/44 extracellular signal-regulated kinase and c-Jun N-terminal kinase[1]. K6PC-5 (1-10 μM; 24 h) also promotes fibroblast proliferation and collagen synthesis in human fibroblasts, inducing intracellular Ca2+ concentration ([Ca2+]i) oscillations[2]. Additionally, K6PC-5 (10, 25, and 50 μM; 48 h) significantly attenuates EBOV infection in EBOV-infected EA.hy926 cells, reduces virus titers in cell supernatants, and decreases VP40 levels in a concentration-dependent manner[3].
In vivo	In intrinsically aged hairless mice (56 weeks old), topical application of 1% K6PC-5 for 2 weeks significantly increased the number of dermal fibroblasts and collagen production, resulting in a notable increase in dermal thickness[2].
Synonyms	K6PC5, K6PC 5

Chemical Properties

Molecular Weight	343.5
Formula	C₁₉H₃₇NO₄
Cas No.	756875-51-1
Smiles	CCCCCCCC(=O)C(CCCCCC)C(=O)NC(CO)CO
Relative Density.	1.007 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 49 mg/mL (142.65 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (9.61 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9112 mL	14.5560 mL	29.1121 mL	145.5604 mL
5 mM	0.5822 mL	2.9112 mL	5.8224 mL	29.1121 mL
10 mM	0.2911 mL	1.4556 mL	2.9112 mL	14.5560 mL
20 mM	0.1456 mL	0.7278 mL	1.4556 mL	7.2780 mL
50 mM	0.0582 mL	0.2911 mL	0.5822 mL	2.9112 mL
100 mM	0.0291 mL	0.1456 mL	0.2911 mL	1.4556 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc