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Mutated EGFR-IN-1

🥰Excellent
Catalog No. T16162Cas No. 1421372-66-8
Alias Osimertinib analog

Mutated EGFR-IN-1 (Osimertinib analog) is a valuable intermediate in designing inhibitors for mutated EGFR, including L858R EGFR, Exon19 deletion activating mutant, and T790M resistance mutant.

Mutated EGFR-IN-1

Mutated EGFR-IN-1

🥰Excellent
Purity: 98.91%
Catalog No. T16162Alias Osimertinib analogCas No. 1421372-66-8
Mutated EGFR-IN-1 (Osimertinib analog) is a valuable intermediate in designing inhibitors for mutated EGFR, including L858R EGFR, Exon19 deletion activating mutant, and T790M resistance mutant.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
25 mg$53In StockIn Stock
50 mg$61In StockIn Stock
100 mg$82In StockIn Stock
200 mg$118In StockIn Stock
500 mg$197In StockIn Stock
1 mL x 10 mM (in DMSO)$45In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.91%
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Product Introduction

Bioactivity
Description
Mutated EGFR-IN-1 (Osimertinib analog) is a valuable intermediate in designing inhibitors for mutated EGFR, including L858R EGFR, Exon19 deletion activating mutant, and T790M resistance mutant.
In vitro
Mutated EGFR inhibitor acts as egfr modulators useful for treating cancer.
SynonymsOsimertinib analog
Chemical Properties
Molecular Weight445.56
FormulaC25H31N7O
Cas No.1421372-66-8
SmilesCOc1cc(N(C)CCN(C)C)c(N)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12
Relative Density.1.21 g/cm3 (Predicted)
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 7.5 mg/mL (16.83 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2444 mL11.2218 mL22.4437 mL112.2183 mL
5 mM0.4489 mL2.2444 mL4.4887 mL22.4437 mL
10 mM0.2244 mL1.1222 mL2.2444 mL11.2218 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

OsimertinibMutated EGFR-IN-1Mutated EGFRIN1Mutated EGFR IN 1InhibitorinhibitHER1ErbB-1Epidermal growth factor receptorEGFRT790MEGFRL858REGFRExon 19 deletion/T790MEGFR(Exon 19 deletion/T790M)EGFR (T790M)EGFR (L858R)EGFR
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