Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 33.00 | |
2 mg | In stock | $ 46.00 | |
5 mg | In stock | $ 76.00 | |
10 mg | In stock | $ 126.00 | |
25 mg | In stock | $ 259.00 | |
50 mg | In stock | $ 417.00 | |
100 mg | In stock | $ 622.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 84.00 |
Description | Sulfopin is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17nM. Sulfopin blocks Myc-driven tumors in vivo. |
In vitro | Sulfopin (2μM, HEK293 cells, 48 hours) downregulates Myc transcription. Sulfopin (1μM, 2.5μM, PATU-8988T cells, 4 days) shows a significant reduction in the member of synthesis (S)-phase cells and a corresponding increase of growth 1 (G1)-phase cells.[1] |
In vivo | Sulfopin (40mg/kg, p.o., bis in die/qualer in die for 7 days) regresses neuroblastoma in mice. Sulfopin (20-40mg/kg, i.p., daily for days) inhibits pancreatic cancer progression in mice.[1] |
Synonyms | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- |
Molecular Weight | 281.8 |
Formula | C11H20ClNO3S |
CAS No. | 2451481-08-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (319.38 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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sulfopin 2451481-08-4 Others neuroblastoma antiproliferative PIN1-3 tumors cancer pancreatic Inhibitor inhibit cells HEK293 Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- inhibitor