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Carotegrast (Synonyms: HCA-2969, HCA2969, HCA 2969)

Name: Carotegrast
Brand: TargetMol
SKU: T14876
Price: 84 USD
Availability: InStock
Rating: 5 (10 reviews)

Catalog No. T14876 Copy Product Info

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Carotegrast is a selective α4 integrin antagonist that inhibits the migration of inflammatory cells to the intestinal mucosa by blocking the interaction between α4β1/α4β7 integrins and their ligands. Carotegrast is used in research and clinical practice for the treatment of inflammatory bowel diseases such as ulcerative colitis; it exerts local anti-inflammatory effects and results in low systemic exposure.

Carotegrast

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Catalog No. T14876

Synonyms HCA-2969, HCA2969, HCA 2969

Cas No. 401904-75-4

Pack Size	Price	USA Stock	Global Stock	Quantity
1 mg	$84	-	In Stock
2 mg	Preferential	-	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Appearance:Solid

Color:Yellow

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COA

Product Introduction

Bioactivity

Description	Carotegrast is a selective α4 integrin antagonist that inhibits the migration of inflammatory cells to the intestinal mucosa by blocking the interaction between α4β1/α4β7 integrins and their ligands. Carotegrast is used in research and clinical practice for the treatment of inflammatory bowel diseases such as ulcerative colitis; it exerts local anti-inflammatory effects and results in low systemic exposure.
Targets&IC50	Jurkat cells:5.4 nM (EC50)
Synonyms	HCA-2969, HCA2969, HCA 2969

Chemical Properties

Molecular Weight	555.41
Formula	C₂₇H₂₄Cl₂N₄O₅
Cas No.	401904-75-4
Smiles	O=C1C=2C(N(C)C(=O)N1C3=CC=C(C[C@H](NC(=O)C4=C(Cl)C=CC=C4Cl)C(O)=O)C=C3)=CC=C(N(C)C)C2
Relative Density.	1.436 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (180.05 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8005 mL	9.0024 mL	18.0047 mL	90.0236 mL
5 mM	0.3601 mL	1.8005 mL	3.6009 mL	18.0047 mL
10 mM	0.1800 mL	0.9002 mL	1.8005 mL	9.0024 mL
20 mM	0.0900 mL	0.4501 mL	0.9002 mL	4.5012 mL
50 mM	0.0360 mL	0.1800 mL	0.3601 mL	1.8005 mL
100 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.9002 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc