Shopping Cart
- Remove All
- Your shopping cart is currently empty
Anti-TrkB Antibody (1M503) is a Mouse antibody targeting TrkB. Anti-TrkB Antibody (1M503) can be used in ELISA(Det).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
20 μL | 65 € | 7-10 days | |
100 μL | 189 € | 7-10 days |
Description | Anti-TrkB Antibody (1M503) is a Mouse antibody targeting TrkB. Anti-TrkB Antibody (1M503) can be used in ELISA(Det). |
Alias | trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB |
Ig Type | Monoclonal Mouse IgG1 |
Clone | 1M503 |
Reactivity | Human |
Application | ELISA(Det) |
Antibody Type | Monoclonal |
Host Species | Mouse |
Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TrkB / NTRK2 (rh TrkB / NTRK2; TMPY-00751; NP_001007098.1; Met1-His430). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
Purification | Protein A |
Appearance | Liquid |
Formulation | 0.2 μm filtered solution in PBS |
Research Background | TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins includenerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy |
Conjucates | Unconjugated |
Immunogen | Recombinant Human TrkB / NTRK2 Protein (TMPY-00751) |
Antigen Species | Human |
Biology Area | Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets |
Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
Transport | Shipping with blue ice. |
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.