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Anti-TrkB Antibody (1M503) (Synonyms: trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP1...)

Catalog No. TMAY-00167 Copy Product Info
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Anti-TrkB Antibody (1M503) is a Mouse antibody targeting TrkB. Anti-TrkB Antibody (1M503) can be used in ELISA(Det).

Anti-TrkB Antibody (1M503)

Copy Product Info
🥰Excellent
Catalog No. TMAY-00167
Synonyms trk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB

Anti-TrkB Antibody (1M503) is a Mouse antibody targeting TrkB. Anti-TrkB Antibody (1M503) can be used in ELISA(Det).

Anti-TrkB Antibody
(1M503)
Pack SizePriceUSA StockGlobal StockQuantity
20 μL$697-10 days7-10 days
100 μL$1997-10 days7-10 days
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction

Bioactivity
Description
Anti-TrkB Antibody (1M503) is a Mouse antibody targeting TrkB. Anti-TrkB Antibody (1M503) can be used in ELISA(Det).
Synonymstrk-B, TRKB, Tkrb, neurotrophic tyrosine kinase, receptor, type 2, GP145-TrkB/GP95-TrkB, GP145-TrkB
Ig Type
Mouse IgG1
Clone
1M503
Reactivity
Human
Specificity
Human TrkB
Application
ELISA(Det)
Antibody Type
Monoclonal
Host SpeciesMouse
ConstructionThis antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human TrkB / NTRK2 (rh TrkB / NTRK2; TMPY-00751; NP_001007098.1; Met1-His430). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundTrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins includenerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Protein: Human TrkB / NTRK2 Protein (TMPY-00751)
Antigen Species
Human
Biology Area
Receptor Tyrosine Kinases (RTKs), Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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