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NP-1815-PX
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Catalog No. T71155Cas No. 1239578-80-3
NP-1815-PX is a selective P2X4 receptor antagonist with anti-inflammatory and analgesic properties. It inhibits guinea pig tracheal/bronchial smooth muscle contraction and can be used to study chronic pain.
NP-1815-PX
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Purity: 99.39%
Catalog No. T71155Cas No. 1239578-80-3
NP-1815-PX is a selective P2X4 receptor antagonist with anti-inflammatory and analgesic properties. It inhibits guinea pig tracheal/bronchial smooth muscle contraction and can be used to study chronic pain.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $293 | - | In Stock | |
| 5 mg | $722 | - | In Stock | |
| 10 mg | $987 | - | In Stock | |
| 25 mg | $1,520 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.39%
Appearance:Solid
Color:White
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Product Introduction
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Chemical Properties
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| Description | NP-1815-PX is a selective P2X4 receptor antagonist with anti-inflammatory and analgesic properties. It inhibits guinea pig tracheal/bronchial smooth muscle contraction and can be used to study chronic pain. |
| Targets&IC50 | P2X4 receptor (human):0.26 μM |
| In vitro | NP-1815-PX is a novel selective antagonist of P2X4R. NP-1815-PX effectively inhibited the increase of [Ca2+]i in P2x4R-mediated HP2x4R-1321N1 cells in a concentration-dependent manner, with IC50 value of 0.26 μM for hP2X4R. [1] |
| In vivo | In a mouse model of chronic pain, NP-1815-PX inhibited mechanical abnormal pain induced by nerve damage without any change in basal pain sensitivity or motor function. NP-1815-PX showed inhibitory effect on mechanical abnormal pain in a herpes pain model. [1] |
| Molecular Weight | 424.41 |
| Formula | C21H13N4NaO3S |
| Cas No. | 1239578-80-3 |
| Smiles | O=C1NC2=C(N(C(C1)=O)C3=CC=CC(C4=NOC([N-]4)=S)=C3)C=CC5=C2C=CC=C5.[Na+] |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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