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Pimivalimab
(Synonyms: JTX-4014) Copy Product Info
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Synonyms: JTX-4014
Catalog No. T77164 Copy Product Info
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Pimivalimab (JTX-4014) is a high-affinity, fully human IgG4 monoclonal antibody targeting the cell surface receptor PD-1. By blocking the interaction between PD-1 and its ligands PD-L1 and PD-L2, the antibody reverses the immunosuppressed state of T cells and enhances the anti-tumor immune response against various solid tumors. It is frequently studied as a monotherapy or in combination with other therapies, such as LILRB2 inhibitors.
Pimivalimab
Cas No. 2293951-22-9
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| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $413 | - | In Stock | |
| 5 mg | $1,230 | - | In Stock | |
| 10 mg | $1,990 | - | In Stock | |
| 25 mg | $3,690 | - | In Stock | |
| 50 mg | $5,890 | - | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Purity:97.3% (SDS-PAGE); 95.6% (SEC-HPLC)
Appearance:Liquid
Color:Transparent
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Product Introduction
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| Description | Pimivalimab (JTX-4014) is a high-affinity, fully human IgG4 monoclonal antibody targeting the cell surface receptor PD-1. By blocking the interaction between PD-1 and its ligands PD-L1 and PD-L2, the antibody reverses the immunosuppressed state of T cells and enhances the anti-tumor immune response against various solid tumors. It is frequently studied as a monotherapy or in combination with other therapies, such as LILRB2 inhibitors. |
| Synonyms | JTX-4014 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Formulation | Supplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition. |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Uniprot ID | |
| Target | PD-1 |
| Molecular Weight | 144.48 kDa (Predicted) |
| Cas No. | 2293951-22-9 |
| Isotype | Human IgG4 kappa |
| Recommended Isotype Control |
| Storage | Store at low temperature Store at -20°C Shipping with blue ice/Shipping at ambient temperature. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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