Shopping Cart
- Remove All
- Your shopping cart is currently empty
Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5'-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $34 | In Stock | |
50 mg | $48 | In Stock | |
100 mg | $68 | In Stock | |
500 mg | $163 | In Stock |
Description | Pemetrexed disodium heptahydrate (LY231514) is an antifolate that inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinyl-adenosine 5'-monophosphate (GARMT) with K_i values of 1.3 nM, 7.2 nM, and 65 nM respectively. This inhibits the formation of precursor purine and pyrimidine nucleotides and cancer cell proliferation, making it suitable for research into pleural mesothelioma and non-small cell lung cancer (NSCLC). |
Targets&IC50 | TS:1.3 nM (Ki), GARFT:65 nM (Ki), DHFR:7.2 nM (Ki) |
In vivo | The survival analysis results showed that the survival time of mice treated with Pemetrexed disodium heptahydrate combined with Pemetrexed was significantly longer than that of mice treated with Pemetrexed disodium heptahydrate alone, rat IgG combined with Pemetrexed, or those receiving no treatment. [2] |
Molecular Weight | 597.49 |
Formula | C20H33N5Na2O13 |
Cas No. | 357166-29-1 |
Smiles | O.O.O.O.O.O.O.[Na+].[Na+].Nc1nc(=O)c2c(CCc3ccc(cc3)C(=O)NC(CCC([O-])=O)C([O-])=O)c[nH]c2[nH]1 |
Color | White |
Appearance | Solid |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 80.00 mg/mL (133.89 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O
|
Copyright © 2015-2025 TargetMol Chemicals Inc. All Rights Reserved.