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Brofaromine

Name: Brofaromine
Brand: TargetMol
SKU: T10617
Rating: 4.5 (1 reviews)

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Catalog No. T10617Cas No. 63638-91-5

Alias CGP 11305A

Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).

Brofaromine

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Catalog No. T10617Alias CGP 11305ACas No. 63638-91-5

Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$118	5 days	5 days
5 mg	$196	5 days	5 days
25 mg	$626	6-8 weeks	6-8 weeks
50 mg	$814	6-8 weeks	6-8 weeks
100 mg	$1,240	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$222	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Brofaromine (CGP 11305A) is an MAO inhibitor (IC50: 0.2 μM for MAO-A).
Targets&IC50	MAO-A:0.2 μM
In vitro	To assess whether the protective effect is related to MAO-A inhibition or another mechanism, the activity of Brofaromine on MAO-A in cultured cortical cells is determined. The cells exhibit significant MAO-A activity, which Brofaromine inhibits in a concentration-dependent manner (IC50: 0.19 μM; Hill coefficient: 0.96), with nearly complete inhibition at 10 μM. The IC50 range of Brofaromine is 0.01 μM to 0.1 μM.
Synonyms	CGP 11305A

Chemical Properties

Molecular Weight	310.19
Formula	C₁₄H₁₆BrNO₂
Cas No.	63638-91-5
Smiles	COc1cc(Br)c2oc(cc2c1)C1CCNCC1
Relative Density.	1.386 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (805.96 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (16.12 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.2238 mL	16.1192 mL	32.2383 mL	161.1915 mL
5 mM	0.6448 mL	3.2238 mL	6.4477 mL	32.2383 mL
10 mM	0.3224 mL	1.6119 mL	3.2238 mL	16.1192 mL
20 mM	0.1612 mL	0.8060 mL	1.6119 mL	8.0596 mL
50 mM	0.0645 mL	0.3224 mL	0.6448 mL	3.2238 mL
100 mM	0.0322 mL	0.1612 mL	0.3224 mL	1.6119 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc