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CADD522

Name: CADD522
Brand: TargetMol
SKU: T8334
Price: 43 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T8334Cas No. 199735-88-1

Alias MFCD00167693

CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity

CADD522

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Purity: 97.74%

Catalog No. T8334Alias MFCD00167693Cas No. 199735-88-1

CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity

Pack Size	Price	Availability
5 mg	$43	In Stock
10 mg	$61	In Stock
25 mg	$133	In Stock
50 mg	$226	In Stock
100 mg	$397	In Stock
1 mL x 10 mM (in DMSO)	$48	In Stock

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Batch Information

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Purity:97.74%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	CADD522 (MFCD00167693) is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding with an IC50 of 10 nM, with antitumor activity
Targets&IC50	RUNX2:10 nM
In vitro	CADD522 is a potent inhibitor of runt-related transcription factor-2 (RUNX2)-DNA binding( IC50 of 10 nM), has antitumor activity
Synonyms	MFCD00167693

Chemical Properties

Molecular Weight	326.17
Formula	C₁₅H₁₃Cl₂NO₃
Cas No.	199735-88-1
Smiles	OC(=O)C1C2CC(C=C2)C1C(=O)NC1=CC=C(Cl)C(Cl)=C1
Relative Density.	1.529 g/cm3 (Predicted)
Color	White
Appearance	solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 245 mg/mL (751.14 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0659 mL	15.3294 mL	30.6589 mL	153.2943 mL
5 mM	0.6132 mL	3.0659 mL	6.1318 mL	30.6589 mL
10 mM	0.3066 mL	1.5329 mL	3.0659 mL	15.3294 mL
20 mM	0.1533 mL	0.7665 mL	1.5329 mL	7.6647 mL
50 mM	0.0613 mL	0.3066 mL	0.6132 mL	3.0659 mL
100 mM	0.0307 mL	0.1533 mL	0.3066 mL	1.5329 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc