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DS-22-inf-021
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Catalog No. T86306Cas No. 945170-74-1
DS-22-inf-021, a neuraminidase (NA) inhibitor, exhibits antiviral activity against influenza viruses [1].
DS-22-inf-021
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Catalog No. T86306Cas No. 945170-74-1
DS-22-inf-021, a neuraminidase (NA) inhibitor, exhibits antiviral activity against influenza viruses [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | DS-22-inf-021, a neuraminidase (NA) inhibitor, exhibits antiviral activity against influenza viruses [1]. |
| In vitro | DS-22-inf-021 inhibits the neuraminidase (NA) activity of IBV (B/Samara/32/2018 Yamagata lineage) and oseltamivir-resistant IAV A/Vladivostok/2/2009 (H1N1 pdm09) carrying the H275Y mutation, with IC50 values of 9.1 μM and 14.7 μM, respectively [1]. Additionally, DS-22-inf-021 (0.5-50 μM, 10 hours) demonstrates antiviral activity in MDCK cells infected with both IAV and IBV strains [1]. |
| In vivo | DS-22-inf-021 administered at doses ranging from 20-100 mg/kg via intraperitoneal injection twice daily for five days significantly enhanced survival rates in mice infected with IAV and IBV [1]. The study involved eight-week-old female BALB/c mice nasally inoculated with five 50% lethal doses of IAV and IBV, using a 50 μL volume [1]. Doses included 20, 50, and 100 mg/kg. Administration occurred two hours post-infection via intraperitoneal injection. At the highest dose of 100 mg/kg, survival rates reached 85%. Notably, for the B/Samara/32/2018 strain, the mice treated with 100 mg/kg of DS-22-inf-021 exhibited a 100% survival rate. |
| Molecular Weight | 337.42 |
| Formula | C20H23N3O2 |
| Cas No. | 945170-74-1 |
| Smiles | N(C(=O)C1=CC=CC=C1)C2=CC=C(NC(NC3CCCCC3)=O)C=C2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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