18:1 PEG1000 PE is a PEG-lipid functional end group used in the synthesis of liposomes (LPs) and for designing conjugated polymer nanoparticles. Liposome nanoparticles (LNPs) can be further coupled with other biomolecules through biotin modification and a carboxyl end. Functionalized nanoparticles are applicable for the targeted labeling of specific cell proteins. Using streptavidin as a linker, biotin-modified PEG-lipid conjugated polymer nanoparticles can bind with biotinylated antibodies on cell surface receptors, facilitating fluorescence-based imaging and sensing applications.