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Anti-MMP-2 Antibody (5E993)

😃Good
Catalog No. TMAY-00231
Alias MMP-2, matrix metallopeptidase 2, GelA, Clg4a

Anti-MMP-2 Antibody (5E993) is a Rabbit antibody targeting MMP-2. Anti-MMP-2 Antibody (5E993) can be used in ELISA.

Anti-MMP-2 Antibody (5E993)

Anti-MMP-2 Antibody (5E993)

😃Good
Catalog No. TMAY-00231Alias MMP-2, matrix metallopeptidase 2, GelA, Clg4a
Anti-MMP-2 Antibody (5E993) is a Rabbit antibody targeting MMP-2. Anti-MMP-2 Antibody (5E993) can be used in ELISA.
Pack SizePriceAvailabilityQuantity
20 μL$94 7-10 days
100 μL$292 7-10 days
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Product Introduction

Bioactivity
Description
Anti-MMP-2 Antibody (5E993) is a Rabbit antibody targeting MMP-2. Anti-MMP-2 Antibody (5E993) can be used in ELISA.
AliasMMP-2, matrix metallopeptidase 2, GelA, Clg4a
Ig Type
Monoclonal Rabbit IgG
Clone
5E993
Reactivity
Human
Application
ELISA
Recommended Dose
ELISA: 1:5000-1:10000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionThis antibody was obtained from a rabbit immunized with purified, recombinant Human MMP-2 (rh MMP-2; TMPY-01477; NP_004521.1; Met 1-Cys660).
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundMatrix Metalloproteinase-2 (MMP-2) is an enzyme that degrades components of the extracellular matrix and thus plays a pivotal role in cell migration during physiological and pathological processes. MMP-2 expression is dependent on extracellular matrix metalloproteinase inducer (EMMPRIN), Her2/neu, growth factors, cytokines, and hormones. Pro-MMP-2 activation needs MT1-MMP and TIMP-2 contribution. MMP-2 is changed in distribution and increased in amount in the ventral cochlear nucleus after unilateral cochlear ablation. A low level of MMP-2 is linked to a favorable prognosis in patients with a hormone receptor-negative tumor, usually associated with high risk. As a zymogen requiring proteolytic activation for catalytic activity, MMP-2 has been implicated broadly in the invasion and metastasis of many cancer model systems, including human breast cancer (HBC). Blocking MMP-2 secretion and activation during breast carcinoma development may decrease metastasis. The detection of active MMP-2 alone or the rate of pro-MMP-2 and active MMP-2 is considered a very sensitive indicator of cancer metastasis. Modulation of MMP-2 expression and activation through specific inhibitors and activators may thus provide a new mechanism for breast cancer treatment.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
Recombinant Human MMP-2 protein (TMPY-01477)
Antigen Species
Human
Biology Area
Cancer Drug Targets
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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