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Rosiglitazone maleate

Name: Rosiglitazone maleate
Brand: TargetMol
SKU: T1622
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T1622Cas No. 155141-29-0

Alias BRL 49653C, BRL 49653

Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.

Rosiglitazone maleate

🥰Excellent

Purity: 99.51%

Catalog No. T1622Alias BRL 49653C, BRL 49653Cas No. 155141-29-0

Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.

Pack Size	Price	Availability
50 mg	$29	In Stock
100 mg	$48	In Stock
500 mg	$147	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock

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Purity:99.51%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Targets&IC50	PPARγ:42 nM, PPARγ1:30 nM (EC50), PPARγ2:100 nM (EC50)
In vivo	In numerous cell lines, Rosiglitazone has been found to inhibit cholesterol synthesis. It activates the AMP-activated protein kinase (AMPK) complex, which includes the α1 and α2 subunits within the AMPKα subunit, leading to an increase in phosphorylation.
Synonyms	BRL 49653C, BRL 49653

Chemical Properties

Molecular Weight	473.50
Formula	C₂₂H₂₃N₃O₇S
Cas No.	155141-29-0
Smiles	C(=C\C(O)=O)\C(O)=O.C(C1SC(=O)NC1=O)C2=CC=C(OCCN(C)C3=CC=CC=N3)C=C2
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 87.00 mg/mL (183.74 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1119 mL	10.5597 mL	21.1193 mL	105.5966 mL
5 mM	0.4224 mL	2.1119 mL	4.2239 mL	21.1193 mL
10 mM	0.2112 mL	1.0560 mL	2.1119 mL	10.5597 mL
20 mM	0.1056 mL	0.5280 mL	1.0560 mL	5.2798 mL
50 mM	0.0422 mL	0.2112 mL	0.4224 mL	2.1119 mL
100 mM	0.0211 mL	0.1056 mL	0.2112 mL	1.0560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc