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Rosiglitazone maleate

🥰Excellent
Catalog No. T1622Cas No. 155141-29-0
Alias BRL 49653C, BRL 49653

Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.

Rosiglitazone maleate
Other Forms of Rosiglitazone maleate:

Rosiglitazone maleate

🥰Excellent
Purity: 99.51%
Catalog No. T1622Alias BRL 49653C, BRL 49653Cas No. 155141-29-0
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
50 mg$29In StockIn Stock
100 mg$48In StockIn Stock
500 mg$147-In Stock
1 mL x 10 mM (in DMSO)$29In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.51%
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Product Introduction

Bioactivity
Description
Rosiglitazone maleate (BRL 49653) is the maleate salt of rosiglitazone, an orally-active thiazolidinedione with antidiabetic properties and potential antineoplastic activity.
Targets&IC50
PPARγ:42 nM, PPARγ1:30 nM (EC50), PPARγ2:100 nM (EC50)
In vivo
In numerous cell lines, Rosiglitazone has been found to inhibit cholesterol synthesis. It activates the AMP-activated protein kinase (AMPK) complex, which includes the α1 and α2 subunits within the AMPKα subunit, leading to an increase in phosphorylation.
SynonymsBRL 49653C, BRL 49653
Chemical Properties
Molecular Weight473.50
FormulaC22H23N3O7S
Cas No.155141-29-0
SmilesC(=C\C(O)=O)\C(O)=O.C(C1SC(=O)NC1=O)C2=CC=C(OCCN(C)C3=CC=CC=N3)C=C2
Relative Density.no data available
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 87.00 mg/mL (183.74 mM), Sonication is recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.97 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1119 mL10.5597 mL21.1193 mL105.5966 mL
5 mM0.4224 mL2.1119 mL4.2239 mL21.1193 mL
10 mM0.2112 mL1.0560 mL2.1119 mL10.5597 mL
20 mM0.1056 mL0.5280 mL1.0560 mL5.2798 mL
50 mM0.0422 mL0.2112 mL0.4224 mL2.1119 mL
100 mM0.0211 mL0.1056 mL0.2112 mL1.0560 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

TRPVChannelTRPV ChannelTRPChannelTRP ChannelRosiglitazonePPARγPPARFerroptosisBRL-49653BRL49653Autophagy
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