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4-(1-Phenylethyl)resorcinol

Name: 4-(1-Phenylethyl)resorcinol
Brand: TargetMol
SKU: T66491
Rating: 4.5 (1 reviews)

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Catalog No. T66491Cas No. 85-27-8

Alias Phenylethyl resorcinol, 4-(1-Phenylethyl)benzene-1,3-diol

4-(1-Phenylethyl)resorcinol (4-(1-Phenylethyl)benzene-1,3-diol) is a skin brightening agent that is a cosmetic additive. It works by inhibiting melanin production, reducing the appearance of dark spots, hyperpigmentation and uneven skin tone, and brightening the skin tone to reduce dullness.4-(1-Phenylethyl)resorcinol is generally regarded as safe in the cosmetic industry, and is widely used in several countries and regions.

4-(1-Phenylethyl)resorcinol

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Purity: 98.48%

Catalog No. T66491Alias Phenylethyl resorcinol, 4-(1-Phenylethyl)benzene-1,3-diolCas No. 85-27-8

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	7-10 days	7-10 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.48%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS

Product Introduction

4-(1-Phenylethyl)resorcinol AI Summary

4-(1-Phenylethyl)resorcinol demonstrates multiple bioactivities, primarily as a tyrosinase inhibitor and an antiviral agent. It shows significant inhibition of tyrosinase, with an IC50 value of 100.0 nM as determined by an inhibition assay. Additionally, it inhibits human tyrosinase enzymes, presenting a Ki of 24,000 nM and an IC50 of 131,000 nM in HEK 293 cell assays using L-DOPA as a substrate, and an IC50 of 300.0 nM for mushroom tyrosinase using L-tyrosine as a substrate. This compound also exhibits antiviral properties by inhibiting the SARS-CoV-2 3CL-Pro protease by 12.53% at a concentration of 20 µM, and reduces SARS-CoV-2 induced cytotoxicity in VERO-6 cells by 0.14% at 10 µM after 48 hours exposure to 0.01 MOI of the virus. These activities suggest its potential use in skin-lightening, anti-aging applications, and antiviral therapies..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description

Synonyms

Phenylethyl resorcinol, 4-(1-Phenylethyl)benzene-1,3-diol

Chemical Properties

Molecular Weight	214.26
Formula	C₁₄H₁₄O₂
Cas No.	85-27-8
Smiles	CC(c1ccccc1)c1ccc(O)cc1O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (233.36 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (11.67 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.6672 mL	23.3361 mL	46.6723 mL	233.3613 mL
5 mM	0.9334 mL	4.6672 mL	9.3345 mL	46.6723 mL
10 mM	0.4667 mL	2.3336 mL	4.6672 mL	23.3361 mL
20 mM	0.2334 mL	1.1668 mL	2.3336 mL	11.6681 mL
50 mM	0.0933 mL	0.4667 mL	0.9334 mL	4.6672 mL
100 mM	0.0467 mL	0.2334 mL	0.4667 mL	2.3336 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc