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Phenindione

Name: Phenindione
Brand: TargetMol
SKU: T0514
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0514Cas No. 83-12-5

Alias Rectadione, Phenylindione, phenylindandione

Phenindione (Rectadione) is an indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects.

Phenindione

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Purity: 98.17%

Catalog No. T0514Alias Rectadione, Phenylindione, phenylindandioneCas No. 83-12-5

Pack Size	Price	USA Warehouse	Global Warehouse
100 mg	$39	In Stock	In Stock
500 mg	$83	In Stock	In Stock
1 g	$121	In Stock	In Stock
2 g	$179	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.17%

Appearance:Solid

Color:White

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COA LCMS HNMR

Product Introduction

Phenindione AI Summary

Phenindione exhibits a variety of pharmacological activities, including significant inhibition of 5-lipoxygenase activity in RBL-1 cells with an IC50 value of 15000 nM and hypolipidemic activity in CF1 male mice at 20 mg/kg per day, effectively reducing serum cholesterol and triglyceride levels. Moreover, it demonstrates diverse bioactivities, including inhibiting various molecular targets such as lamin A splicing, Tau fibril formation, and histone lysine methyltransferase G9a, as well as exhibiting activator potential for Cytochrome P450 3A4. The compound also impacts blood parameters and enzyme levels significantly, suggesting a broad effect on blood composition and enzyme activities. Notably, it shows moderate liver toxicity, including cytolytic and cholestatic effects, but no chronic liver damage or tumors have been reported. Furthermore, Phenindione displays antiviral activities, including inhibition of SARS-CoV-2 3CL-Pro protease and reduction of SARS-CoV-2 induced cytotoxicity in Vero E6 and Caco-2 cells, though its antiviral potency is relatively weak. Additionally, it moderately inhibits human HDAC6, and while showing some binding affinity toward various receptors, its overall bioactivity in evaluated assays tends to be limited with AC50 values often exceeding 10,000 nM..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Phenindione (Rectadione) is an indandione that has been used as an anticoagulant. Phenindione has actions similar to WARFARIN, but it is now rarely employed because of its higher incidence of severe adverse effects.
Synonyms	Rectadione, Phenylindione, phenylindandione

Chemical Properties

Molecular Weight	222.24
Formula	C₁₅H₁₀O₂
Cas No.	83-12-5
Smiles	O=C1C(C(=O)c2ccccc12)c1ccccc1
Relative Density.	1.343g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (224.98 mM), Sonication is recommended.

Ethanol: 12 mg/mL (54 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (9 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4996 mL	22.4982 mL	44.9964 mL	224.9820 mL
5 mM	0.8999 mL	4.4996 mL	8.9993 mL	44.9964 mL
10 mM	0.4500 mL	2.2498 mL	4.4996 mL	22.4982 mL
20 mM	0.2250 mL	1.1249 mL	2.2498 mL	11.2491 mL
50 mM	0.0900 mL	0.4500 mL	0.8999 mL	4.4996 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0450 mL	0.2250 mL	0.4500 mL	2.2498 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc