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Etofylline clofibrate

Name: Etofylline clofibrate
Brand: TargetMol
SKU: T15256
Rating: 4.5 (1 reviews)

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Catalog No. T15256Cas No. 54504-70-0

Etofylline clofibrate has a hypolipidemic and antithrombotic effect and it also has an agonistic interaction with intimal PGI2.

Etofylline clofibrate

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Catalog No. T15256Cas No. 54504-70-0

Etofylline clofibrate has a hypolipidemic and antithrombotic effect and it also has an agonistic interaction with intimal PGI2.

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$48	5 days	5 days
5 mg	$76	5 days	5 days
1 mL x 10 mM (in DMSO)	$107	5 days	5 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Etofylline clofibrate has a hypolipidemic and antithrombotic effect and it also has an agonistic interaction with intimal PGI2.
In vivo	Etofylline clofibrate administered orally at a dosage of 12 mg/kg demonstrates a moderate initial efficacy with a 12% reduction in disaggregation time from a single dose. The effectiveness of the compound increases significantly with consistent daily usage, achieving a maximum reduction in disaggregation time of 31% after 5 days and 43% after 7 days of consecutive applications.

Chemical Properties

Molecular Weight	420.85
Formula	C₁₉H₂₁ClN₄O₅
Cas No.	54504-70-0
Smiles	Cn1c2ncn(CCOC(=O)C(C)(C)Oc3ccc(Cl)cc3)c2c(=O)n(C)c1=O
Relative Density.	1.37g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 52 mg/mL (123.56 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.94 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3761 mL	11.8807 mL	23.7614 mL	118.8072 mL
5 mM	0.4752 mL	2.3761 mL	4.7523 mL	23.7614 mL
10 mM	0.2376 mL	1.1881 mL	2.3761 mL	11.8807 mL
20 mM	0.1188 mL	0.5940 mL	1.1881 mL	5.9404 mL
50 mM	0.0475 mL	0.2376 mL	0.4752 mL	2.3761 mL
100 mM	0.0238 mL	0.1188 mL	0.2376 mL	1.1881 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc