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Ifebemtinib
(Synonyms: IN-10018, BI-853520) Copy Product Info
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Synonyms: IN-10018, BI-853520
Catalog No. T64167 Copy Product Info
Purity: 99.93%
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Ifebemtinib (BI-853520) is a small-molecule inhibitor, a highly potent FAK inhibitor (IC50=1 nM) with oral efficacy and antiproliferative activity, used in tumor research including breast cancer and ovarian cancer. It exhibits significant antiproliferative activity.
Cas No. 1227948-82-4
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 1 mg | $157 | In Stock | In Stock | |
| 5 mg | $272 | In Stock | In Stock | |
| 10 mg | $409 | In Stock | In Stock | |
| 25 mg | $636 | In Stock | In Stock | |
| 50 mg | $979 | In Stock | In Stock | |
| 100 mg | $1,380 | In Stock | In Stock | |
| 1 mL x 10 mM (in DMSO) | $352 | In Stock | In Stock |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
Batch Information
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Purity:99.93%
Appearance:Solid
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | Ifebemtinib (BI-853520) is a small-molecule inhibitor, a highly potent FAK inhibitor (IC50=1 nM) with oral efficacy and antiproliferative activity, used in tumor research including breast cancer and ovarian cancer. It exhibits significant antiproliferative activity. |
| Targets & IC50 | FAK:1 nM, FER:900 nM, FES:1040 nM |
| In vitro | Methods: Cancer cells were treated with Ifebemtinib at various concentrations and time points to assess cell growth, proliferation, invasion, and FAK phosphorylation levels. Results: Inhibited proliferation and invasion only in 3D culture (0-30 μM, 4-6 days) [1]; inhibited Y397-FAK autophosphorylation (0-10 μM, 24 h) [1]; rapid and effective FAK inhibition with 0.1 μM treatment for 96 h [1]; concentration-dependent inhibition of cancer cell growth (0-3 μM, 2 h) [2]. |
| In vivo | Methods: Tumor-bearing mice with three different cell lines were administered Ifebemtinib (50 mg/kg; once daily; for 0-8 weeks) via oral gavage to observe its inhibitory effect on primary tumor growth. Results: Ifebemtinib treatment significantly inhibited primary tumor growth in all three cell lines.[1] |
| Synonyms | IN-10018, BI-853520 |
| Molecular Weight | 588.55 |
| Formula | C28H28F4N6O4 |
| Cas No. | 1227948-82-4 |
| Smiles | COc1cc(C(=O)NC2CCN(C)CC2)c(F)cc1Nc1ncc(c(Oc2cccc3CN(C)C(=O)c23)n1)C(F)(F)F |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 71.4 mg/mL (121.32 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (5.61 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density. | ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 µL Tween 80 and mix well until fully clarified.
3) Add 450 µL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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Related Tags: Ifebemtinib chemical structure | Ifebemtinib in vivo | Ifebemtinib in vitro | Ifebemtinib formula | Ifebemtinib molecular weight
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