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Anti-PD-L1 Antibody (9Z343)
😃Good
Catalog No. TMAY-00235
Alias Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Anti-PD-L1 Antibody (9Z343) is a Mouse antibody targeting PD-L1. Anti-PD-L1 Antibody (9Z343) can be used in WB.
Anti-PD-L1 Antibody (9Z343)
Anti-PD-L1 Antibody (9Z343)
😃Good
Catalog No. TMAY-00235Alias Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik
Anti-PD-L1 Antibody (9Z343) is a Mouse antibody targeting PD-L1. Anti-PD-L1 Antibody (9Z343) can be used in WB.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $92 | 7-10 days | |
| 100 μL | $198 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Mouse Monoclonal Application: WB Reactivity: Human |
| Alias | Pdl1, Pdcd1lg1, Pdcd1l1, CD274 molecule, B7h1, A530045L16Rik |
| Ig Type | Mouse IgG1 |
| Clone | 9Z343 |
| Reactivity | Human |
| Verified Activity | 1. Anti-PD-L1 mouse monoclonal antibody at 1:500 dilution. -Lane A: K562 Whole Cell Lysate. -Lane B: THP1 Whole Cell Lysate. -Lane C: Raji Whole Cell lysate. -Lysates/proteins at 30 μg per lane. -Secondary -Goat Anti-Mouse IgG (H+L)/HRP at 1/10000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size:33 kDa. -Observed band size:45 kDa. 2. B7-H1 was immunoprecipitated using: -Lane A:0.5 mg K562 Whole Cell Lysate. -4µL anti-B7-H1 mouse monoclonal antibody and 60 μg of Immunomagnetic beads Protein A/G. -Primary antibody: -Anti-B7-H1 mouse monoclonal antibody, at 1:100 dilution. -Secondary antibody: -Clean-Blot IP Detection Reagent (HRP) at 1:1000 dilution. -Developed using the ECL technique. -Performed under reducing conditions. -Predicted band size: 33 kDa. -Observed band size:45 kDa |
| Application | WB |
| Recommended Dose | WB: 1:500-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human PD-L1/B7-H1/CD274 (rh PD-L1/B7-H1/CD274; TMPY-04343; NP_054862.1; Met1-Thr239). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Programmed death-1 ligand-1 (PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. PD-L1/B7-H1 is a member of the growing B7 family of immune molecules and this protein contains one V-like and one C-like Ig domain within the extracellular domain, and together with PD-L2, are two ligands for PD1 which belongs to the CD28/CTLA4 family expressed on activated lymphoid cells. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Blockade: Blocking AntibodiImmune Checkpoint Blockade: PD-L1 / B7-H1 / CImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IHC AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyPD-L1 / B7-H1 / CD274 Immune Checkpoint ProteTargeted Therapy |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human PD-L1/B7-H1/CD274 Protein (TMPY-04343) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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