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TargetMol | Compound Library

Epigenetics Compound Library

Catalog No. L1200

Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence. Epigenetics has the potential to be a key element in a paradigm change of our understanding of aging, development, cancer, heart disease, psychological disorders, and other diseases. For example, Epigenetic modifications have a considerable effect on cancer. Changes in the pattern of histone modifications in the promoter sequences as epigenetic regulation lead to changes in chromatin structure thus may be the cause of altered gene expression by activation of oncogenes. The Epigenetics Compound Library by TargetMol, containing 1360 compounds related to epigenetic regulation, can be used for research in epigenetics, high throughput screening and high content screening for new drugs in epigenetic modification.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

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Catalog No. L1200

Epigenetics Compound Library

sizeIn stock

  • 1 mg
  • 30 μL x 10 mM (in DMSO)
  • 50 μL x 10 mM (in DMSO)
  • 100 μL x 10 mM (in DMSO)
  • 250 μL x 10 mM (in DMSO)
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Product Description Product Description

  • Quantity: well-chosen 1360 compounds related to epigenetic regulation for research in epigenetics, high throughput screening (HTS) and high content screening (HCS) for new drugs;
  • Targets include HDAC, SIRT, HAT, and HMT, etc.;
  • Detailed compound information with structure, target, activity, IC50 value, and biological activity description, providing reference for your experimental design;
  • NMR and LCMS/HPLC validated to ensure high purity and quality.
  • Structurally diverse, medicinally active, and cell permeable;
  • NMR and HPLC validated to ensure high purity and quality;

Advantages Introduction Advantages Introduction

High-Standard Entry Criteria

TargetMol’s Epigenetics Compound Library is curated with stringent entry criteria to ensure that every compound in the collection is structurally well-defined and of high purity. Multiple analytical techniques—such as NMR, HPLC, and LCMS—are employed to verify compound integrity. Through a multi-layered screening process, we exclude mixtures, polymers, and other compounds with undefined structures.

Significant Structural Diversity

TargetMol’s Epigenetics Compound Library features remarkable structural diversity, offering significant advantages in drug discovery. Based on an 85% MACCS fingerprint similarity analysis, the library can be divided into 1,052 clusters, covering a wide range of chemical space. The collection encompasses compounds of varying complexity, from simple to intricate chemical structures. This diversity greatly expands the potential for identifying lead compounds with high affinity and specificity toward target proteins, thereby driving drug innovation. Whether addressing traditional drug targets or emerging, more challenging ones, the Epigenetics Library provides a rich source of candidate compounds, accelerating the pace of drug development.

 Epigenetics Compound Library
Library Diversity Analysis

Superior Drug-likeness

71% compounds in this library comply with Lipinski’s “Rule of Five” (Ro5), indicating favorable bioavailability and permeability.

 Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library  Epigenetics Compound Library
Analysis on Drug-like Property

Multidimensional Pharmacokinetic Analysis

The Epigenetics Compound Library underwent multidimensional ADMET prediction and evaluation, with a systematic analysis of the following six key pharmacokinetic parameters: blood-brain barrier permeability, cardiac toxicity risk (HERG K+ channel inhibition), plasma protein binding affinity, oral absorption, intestinal absorption, and dermal absorption.

 Epigenetics Compound Library  Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library  Epigenetics Compound Library
 Epigenetics Compound Library

Rich Variety of Compounds

Epigenetic modification refers to the regulation of gene expression without altering the DNA sequence, through mechanisms such as DNA methylation, histone modifications (e.g., methylation, acetylation, deacetylation), and non-coding RNA regulation. These processes play critical roles in pathological conditions including cancer, neurodegenerative diseases, and immune disorders. TargetMol’s Epigenetic Compound Library is a carefully curated collection of high-quality bioactive small molecules targeting key epigenetic regulators such as Epigenetic Reader Domains, Histone Methyltransferases, HDACs, Sirtuins, Histone Demethylases, Histone Acetyltransferases, DNA Methyltransferases, and MicroRNAs. This library provides comprehensive support for epigenetics research, target validation, and innovative drug discovery.

 Epigenetics Compound Library

TargetMol’s Epigenetics Compound Library includes 100+ approved drugs authorized by regulatory agencies such as FDA, EMA, PMDA, and NMPA, as well as 270+ clinical candidates currently in trials. In addition, it features 170+ natural compounds derived from plants, animals, and microorganisms, providing comprehensive support for research on epigenetics-related diseases.

 Epigenetics Compound Library

Regular Updates to Compound Libraries

TargetMol ensures compound libraries stay at the forefront of science by regularly updating our database to include the latest approved and marketed drugs.

Flexible Packaging Options

TargetMol provides a variety of standard packaging sizes (such as 30 μL, 50 μL, 100 μL, 250 μL, and 1 mg), and offer customized packaging solutions tailored to specific needs.

Personalized Custom Services

TargetMol offers fully customized screening services, including the design and synthesis of compound libraries. Our highly flexible service is designed to efficiently meet the unique needs of scientists and researchers.

Packaging And Storage Packaging And Storage

  • Powder or pre-dissolved DMSO solutions in 96/384 well plate with optional 2D barcode
  • Shipped with blue ice
  • This compound library is provided at a concentration of 10 mM in DMSO. A small number of compounds may be provided in different solvents or concentrations due to solubility or stability requirements. Please refer to the specific product information for details.

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Apoptosis
Epigenetic Reader Domain
Histone Methyltransferase
HDAC
JAK
PARP
Autophagy
PKC
AMPK
HIF/HIF Prolyl-Hydroxylase
Sirtuin
Histone Demethylase
Aurora Kinase
HIF
Histone Acetyltransferase
Endogenous Metabolite
Antibacterial
CDK
Caspase
STAT
DNA Methyltransferase
FLT
Tyrosine Kinases
NF-κB
Pim
Parasite
Bcl-2 Family
PKA
Akt
HIV Protease
PROTACs
VEGFR
ERK
Reactive Oxygen Species
Wnt/beta-catenin
Mitophagy
Virus Protease
Src
p38 MAPK
Influenza Virus
MicroRNA
TNF
Antibiotic
GSK-3
Antifungal
PI3K
EGFR
mTOR
FGFR
MDM-2/p53
PPAR
ROCK
Bcr-Abl
PDGFR
DNA/RNA Synthesis
Nrf2
Topoisomerase
IL Receptor
Cytochromes P450
COX
Calcium Channel
PAD
Methionine Adenosyltransferase (MAT)
c-RET
AChR
JNK
Casein Kinase
Syk
Monoamine Oxidase
Ferroptosis
Phosphatase
Serine/threonin kinase
Potassium Channel
S6 Kinase
Microtubule Associated
p53
Ligands for Target Protein for PROTAC
Antioxidant
Adenosine Receptor
c-Myc
Nucleoside Antimetabolite/Analog
PDE
MMP
IGF-1R
CaMK
Interleukin
Antiviral
IκB/IKK
GABA Receptor
MEK
NO Synthase
Dehydrogenase
DYRK
HSV
TLR
SARS-CoV
5-HT Receptor
PLK
Anti-infection
c-Kit
Ras
PD-1/PD-L1
IFNAR
RAAS
Histamine Receptor
HBV
MAO
Gamma-secretase
Angiotensin-converting Enzyme (ACE)
Chk
DUB
TGF-beta/Smad
MAPK
SGK
Transferase
HCV Protease
Serine Protease
NR4A
IDO
SIK
LDL
Glucosidase
ROS
Fatty Acid Synthase
DNA Alkylation
Cholinesterase (ChE)
Androgen Receptor
Indoleamine 2,3-Dioxygenase (IDO)
ATP Citrate Lyase
P-gp
HSP
Trk receptor
transporter
HuR
Pyroptosis
ALK
Carboxypeptidase
Beta Amyloid
Reverse Transcriptase
c-Fms
Cannabinoid Receptor
Sodium Channel
HER
Kras
GPCR
NOS
Dopamine Receptor
ADC Cytotoxin
Integrin
YAP
Cholecystokinin Receptor
Adrenergic Receptor
Myosin
Raf
Drug Metabolite
NMDAR
Mitochondrial Metabolism
Antifection
Molecular Glues
Telomerase
OXPHOS
Prostaglandin Receptor
Hippo pathway
DAPK
Tyrosinase
FAK
ROS Kinase
CFTR
MLK
BTK
PGK1
Proteasome
Mdm2
Chloride channel
Proton pump
Adenylyl Cyclase
Carbonic Anhydrase
NPC1L1
DNA-PK
Amino Acids and Derivatives
MyD88
Estrogen/progestogen Receptor
c-Met/HGFR
DNA Alkylator/Crosslinker
BACE
Arrestin
NADPH
PERK
Tie-2
gp120/CD4
GTPase
OCT
MRP
Estrogen Receptor/ERR
ASCT
Photosensitizer
ATG
Antifolate
Liver X Receptor
FXR
Glucokinase
TRP/TRPV Channel
Aryl Hydrocarbon Receptor
IAP
Immunology/Inflammation related
E1/E2/E3 Enzyme
RIP kinase
PAFR
GRK
Glucagon Receptor
Phosphorylase
DNA gyrase
Monoamine Transporter
Guanylate cyclase
Hedgehog/Smoothened
PAK
CCR
CXCR
PTEN
GluR
cAMP
Thrombopoietin Receptor
Lipoxygenase
Orphan Receptor
DNA
SGLT
Beta-Secretase
PSMA
Survivin
Acyltransferase
LRRK2
Free radical scavengers
Aminopeptidase
cGAS
MELK
Ligand for E3 Ligase
Phospholipase
Hydroxylase
NADPH-oxidase
NOD
BMI-1
TAM Receptor
Protease-activated Receptor
Liposome
NOD-like Receptor (NLR)
S1P Receptor