Anti-Phospho-BMX (Tyr566) Polyclonal Antibody 3 is a Rabbit antibody targeting Phospho-BMX (Tyr566). Anti-Phospho-BMX (Tyr566) Polyclonal Antibody 3 can be used in WB.

IgG

Human,Mouse (predicted:Rat,Dog,Pig,Cow,Horse,Rabbit)

WB: 1:500-2000

Polyclonal

KLH conjugated Synthesised phosphopeptide: human BMX around the phosphorylation site of Tyr566

Human

BMX

Cytoplasmic tyrosine-protein kinase BMX

Non-receptor tyrosine kinase that plays central butdiverse modulatory roles in various signaling processes involved inthe regulation of actin reorganization, cell migration, cellproliferation and survival, cell adhesion, and apoptosis.Participates in signal transduction stimulated by growth factorreceptors, cytokine receptors, G-protein coupled receptors, antigenreceptors and integrins. Induces tyrosine phosphorylation of BCAR1in response to integrin regulation. Activation of BMX by integrinsis mediated by PTK2/FAK1, a key mediator of integrin signalingevents leading to the regulation of actin cytoskeleton and cellmotility. Plays a critical role in TNF-induced angiogenesis, andimplicated in the signaling of TEK and FLT1 receptors, 2 importantreceptor families essential for angiogenesis. Required for thephosphorylation and activation of STAT3, a transcription factorinvolved in cell differentiation. Also involved in interleukin-6(IL6) induced differentiation. Plays also a role in programmingadaptive cytoprotection against extracellular stress in differentcell systems, salivary epithelial cells, brain endothelial cells,and dermal fibroblasts. May be involved in regulation ofendocytosis through its interaction with an endosomal proteinRUFY1. May also play a role in the growth and differentiation ofhematopoietic cells; as well as in signal transduction inendocardial and arterial endothelial cells.as in signal transduction inendocardial and arterial endothelial cells.