Shopping Cart
Remove All
Your shopping cart is currently empty
Anti-4EBP1 Antibody (2G39) (Synonyms: PHAS-I, eukaryotic translation initiation factor 4E binding protein 1, B...)
Catalog No. TMAY-00091 Copy Product Info
🥰Excellent
Anti-4EBP1 Antibody (2G39) is a Rabbit antibody targeting 4EBP1. Anti-4EBP1 Antibody (2G39) can be used in ICC/IF.
Anti-4EBP1 Antibody (2G39)
Copy Product Info🥰Excellent
Catalog No. TMAY-00091
Synonyms PHAS-I, eukaryotic translation initiation factor 4E binding protein 1, BP-1, 4E-BP1, 4EBP1
Anti-4EBP1 Antibody (2G39) is a Rabbit antibody targeting 4EBP1. Anti-4EBP1 Antibody (2G39) can be used in ICC/IF.
Anti-4EBP1 Antibody
(2G39)
(2G39)
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 100 μL | $270 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
Add to Cart
Add to Quotation
For research use only—not for human use. No sales to individuals. Use as intended only.
Resource Download
Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
Stability & Storage
| Description | Anti-4EBP1 Antibody (2G39) is a Rabbit antibody targeting 4EBP1. Anti-4EBP1 Antibody (2G39) can be used in ICC/IF. |
| Synonyms | PHAS-I, eukaryotic translation initiation factor 4E binding protein 1, BP-1, 4E-BP1, 4EBP1 |
| Ig Type | Rabbit IgG |
| Clone | 2G39 |
| Reactivity | Human |
| Specificity | Human 4EBP1 |
| Verified Activity | Immunofluorescence staining of Human 4EBP1 in Hela cells. Cells were fixed with 4% PFA, permeabilzed with 0.3% Triton X-100 in PBS, blocked with 10% serum, and incubated with rabbit anti-Human 4EBP1 monoclonal antibody (1:60) at 37°C 1 hour. Then cells were stained with the Alexa Fluor® 594-conjugated Goat Anti-rabbit IgG secondary antibody (red) and counterstained with DAPI (blue). Positive staining was localized to nucleus and cytoplasm. |
| Application | |
| Recommended Dose | ICC-IF: 1:20-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human 4E-BP1 / EIF4EBP1 (rh 4E-BP1 / EIF4EBP1; TMPY-01769; NP_004086.1; Ser2-Ile118). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The translational suppressor eIF4E binding protein-1, 4E-BP1 functions as a key regulator in cellular growth, differentiation, apoptosis and survival. The Eif4ebp1 gene, encoding 4E-BP1, is a direct target of a transcription factor activating transcription factor-4 (ATF4), a master regulator of gene expression in stress responses. 4E-BP1 is characterized by its capacity to bind specifically to eIF4E and inhibit its interaction with eIF4G. Phosphorylation of 4E-BP1 regulates eIF4E availability, and therefore, cap-dependent translation, in cell stress. Binding of eIF4E to eIF4G is inhibited in a competitive manner by 4E-BP1. Phosphorylation of 4E-BP1 decreases the affinity of this protein for eIF4E, thus favouring the binding of eIF4G and enhancing translation. 4E-BP1 is important for beta-cell survival under endoplasmic reticulum (ER) stress. 4E-BP1 mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Recently, 4E-BP1 was found to be a key factor, which converges several oncogenic signals, phosphorylates the molecules, and drives the downstream proliferative signals. Recent studies showed that high expression of phosphorylated 4E-BP-1 (p-4E-BP1) is associated with poor prognosis, tumor progression, or nodal metastasis in different human cancers. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human 4E-BP1 / EIF4EBP1 protein (TMPY-01769) |
| Antigen Species | Human |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
Calculator
Preview
Related Tags: buy Anti-4EBP1 Antibody (2G39) | purchase Anti-4EBP1 Antibody (2G39) | Anti-4EBP1 Antibody (2G39) cost | order Anti-4EBP1 Antibody (2G39)
Generate Quote
Catalog No.: Cas No.:
Add
| Size | Quantity | Unit Price | Amount | Operation |
|---|
Generate Quote
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2026 TargetMol Chemicals Inc. All Rights Reserved.